Review Questions

Abstract

4. The major factors that determine the level of serum leptin are: A. serum insulin and glucose levels. B. adiposity and gender. C. adiposity and serum insulin. D. catecholamines and hexosamine biosynthesis. 5. Leptin resistance: A. as an explanation for obesity, is dependent on the hypothesis that the major role of leptin in the body is to promote weight gain. B. in endothelial cells, results in oxidative stress. C. has been hypothesized to consist of resistance to leptin action in the hypothalamus resulting in weight gain and sensitivity to leptin in peripheral tissues resulting in pathophysiologic effects in obesity. D. may result from genetic defects in the LEP gene.