M. Jan Jacques Michiels, Ph.D. Guest Robert, Yvo Clarke M.D., Ph.D. Brian Smulders, Ph.D Coen D.A Fowler, M. D. Stehouwer
{"title":"Review Questions","authors":"M. Jan Jacques Michiels, Ph.D. Guest Robert, Yvo Clarke M.D., Ph.D. Brian Smulders, Ph.D Coen D.A Fowler, M. D. Stehouwer","doi":"10.1055/s-2005-872408","DOIUrl":null,"url":null,"abstract":"8. Why is the MTHFR 677C>T (Alanine222Valine) polymorphism such an important determinant of homocysteine levels? A. Because the polymorphism reduces MTHFR activity and increases homocysteine, especially at low folate status. B. Because the polymorphism makes the MTHFR enzyme more vulnerable to small increases in temperature. C. Because the polymorphism impairs binding of FAD, which is the cofactor of MTHFR.","PeriodicalId":87139,"journal":{"name":"Seminars in vascular medicine","volume":"5 1","pages":"C-1 - C-5"},"PeriodicalIF":0.0000,"publicationDate":"2005-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2005-872408","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in vascular medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-2005-872408","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
8. Why is the MTHFR 677C>T (Alanine222Valine) polymorphism such an important determinant of homocysteine levels? A. Because the polymorphism reduces MTHFR activity and increases homocysteine, especially at low folate status. B. Because the polymorphism makes the MTHFR enzyme more vulnerable to small increases in temperature. C. Because the polymorphism impairs binding of FAD, which is the cofactor of MTHFR.
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