Proton magnetic resonance spectroscopy (H-MRS) studies of schizophrenia.

L. Rowland, J. Bustillo, J. Lauriello
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引用次数: 27

Abstract

Proton magnetic resonance spectroscopy ((1)H-MRS) is a noninvasive technique that can quantify biochemical compounds in the brain. (1)H-MRS has been used to investigate neural structures implicated in the pathology of schizophrenia. The majority of research has revealed reduced N-acetylaspartate (NAA), an index of neuronal integrity, in frontal and temporal regions of medicated and chronically ill patients with schizophrenia. This review summarizes basic principles of (1)H-MRS, studies of frontal, temporal, subcortical, and cerebellar regions in schizophrenia. Technical and study design limitations are also discussed.
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质子磁共振波谱(H-MRS)研究精神分裂症。
质子磁共振波谱(H-MRS)是一种非侵入性技术,可以量化大脑中的生化化合物。(1)H-MRS已被用于研究与精神分裂症病理有关的神经结构。大多数研究表明,在服用药物和慢性精神分裂症患者的额叶和颞叶区域,神经完整性指标n -乙酰天冬氨酸(NAA)减少。本文综述了H-MRS的基本原理,以及对精神分裂症患者额叶、颞叶、皮质下和小脑区域的研究。还讨论了技术和研究设计的局限性。
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