Sclerostin inhibits osteoblast differentiation without affecting BMP2/SMAD1/5 or Wnt3a/β-catenin signaling but through activation of platelet-derived growth factor receptor signaling in vitro.

C. Thouverey, J. Caverzasio
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在体外研究中,Sclerostin不影响BMP2/SMAD1/5或Wnt3a/β-catenin信号,而是通过激活血小板来源的生长因子受体信号来抑制成骨细胞分化。
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