Structural connectivity between the hippocampus and cortical/subcortical area relates to cognitive impairment in schizophrenia but not in mood disorders

IF 2 4区 心理学 Q2 PSYCHOLOGY Journal of Neuropsychology Pub Date : 2022-10-28 DOI:10.1111/jnp.12298
Natsuko Ikeda, Shinichi Yamada, Kasumi Yasuda, Shinya Uenishi, Atsushi Tamaki, Takuya Ishida, Michiyo Tabata, Tomikimi Tsuji, Sohei Kimoto, Shun Takahashi
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引用次数: 2

Abstract

Cognitive impairment in schizophrenia and other psychiatric disorders is a challenge to be overcome in order to maintain patients' quality of life and social function. The neurological pathogenesis of cognitive impairment requires further elucidation. In general, the hippocampus interacts between the cortical and subcortical areas for information processing and consolidation and has an important role in memory. We examined the relationship between structural connectivity of the hippocampus and cortical/subcortical areas and cognitive impairment in schizophrenia, major depressive disorder and bipolar disorder. Subjects comprised 21 healthy controls, 19 patients with schizophrenia, 20 patients with bipolar disorder and 18 patients with major depressive disorder. Diffusion-weighted tensor images data were processed using ProbtrackX2 to calculate the structural connectivity between the hippocampus and cortical/subcortical areas. Cognitive function was assessed using the Brief Assessment of Cognition in schizophrenia composite score. Hippocampal structural connectivity index was significantly correlated with composite score in the schizophrenia group but not in the healthy control, major depressive disorder or bipolar disorder groups. There were no statistically significant differences in hippocampal structural connectivity index between the four groups. Structural connectivity between the hippocampus and cortical/subcortical areas is suggested to be a pathophysiological mechanism of comprehensive cognitive impairment in schizophrenia.

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海马体与皮质/皮质下区之间的结构连通性与精神分裂症的认知障碍有关,但与情绪障碍无关
精神分裂症和其他精神疾病的认知障碍是维持患者生活质量和社会功能的一个挑战。认知障碍的神经学发病机制有待进一步阐明。一般来说,海马体在皮层和皮层下区域之间相互作用,进行信息加工和巩固,在记忆中起重要作用。我们研究了精神分裂症、重度抑郁症和双相情感障碍患者海马和皮质/皮质下区结构连通性与认知障碍之间的关系。研究对象包括21名健康对照、19名精神分裂症患者、20名双相情感障碍患者和18名重度抑郁症患者。采用ProbtrackX2对弥散加权张量图像数据进行处理,计算海马与皮质/皮质下区之间的结构连通性。认知功能采用精神分裂症综合评分简易认知评估。精神分裂症组海马结构连通性指数与综合评分显著相关,而健康对照组、重度抑郁症和双相情感障碍组海马结构连通性指数与综合评分无显著相关。四组海马结构连通性指数差异无统计学意义。海马与皮质/皮质下区之间的结构连接可能是精神分裂症患者综合认知障碍的病理生理机制。
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来源期刊
Journal of Neuropsychology
Journal of Neuropsychology 医学-心理学
CiteScore
4.50
自引率
4.50%
发文量
34
审稿时长
>12 weeks
期刊介绍: The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.
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