Testing the dopamine overdose hypothesis in action control: A study in people with Parkinson's disease

IF 2 4区 心理学 Q2 PSYCHOLOGY Journal of Neuropsychology Pub Date : 2022-10-27 DOI:10.1111/jnp.12296
Marit F. L. Ruitenberg, Elger L. Abrahamse, Patrick Santens, Wim Notebaert
{"title":"Testing the dopamine overdose hypothesis in action control: A study in people with Parkinson's disease","authors":"Marit F. L. Ruitenberg,&nbsp;Elger L. Abrahamse,&nbsp;Patrick Santens,&nbsp;Wim Notebaert","doi":"10.1111/jnp.12296","DOIUrl":null,"url":null,"abstract":"<p>Prior work on patients with Parkinson's disease (PD) has shown that the administration of dopaminergic medication in the early to intermediate stages of PD benefits (motor) functions associated with the dopamine-depleted dorsal striatal circuitry but may ‘overdose’ and interfere with (cognitive) functions associated with the relatively intact ventral striatal circuitry. The present study aimed to elucidate this so-called <i>dopamine overdose hypothesis</i> for the action control domain. Using a within-subject design in a sample of 13 people with PD, we evaluated the effect of dopaminergic medication on two cognitive processes underlying goal-directed behaviour, namely action selection and initiation through event binding and conflict adaptation. We also investigated whether individual differences in the magnitude of medication effects were associated across these processes. Results showed no indications that dopaminergic medication affects action selection and initiation or conflict adaptation in PD patients. Additionally, we observed no correlations between both cognitive processes nor between individual differences in medication effects. Our findings do not support the notion that dopaminergic medication modulates action control processes, suggesting that the dopamine overdose hypothesis may only apply to a specific set of cognitive processes and should potentially be refined.</p>","PeriodicalId":197,"journal":{"name":"Journal of Neuropsychology","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jnp.12296","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neuropsychology","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jnp.12296","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHOLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Prior work on patients with Parkinson's disease (PD) has shown that the administration of dopaminergic medication in the early to intermediate stages of PD benefits (motor) functions associated with the dopamine-depleted dorsal striatal circuitry but may ‘overdose’ and interfere with (cognitive) functions associated with the relatively intact ventral striatal circuitry. The present study aimed to elucidate this so-called dopamine overdose hypothesis for the action control domain. Using a within-subject design in a sample of 13 people with PD, we evaluated the effect of dopaminergic medication on two cognitive processes underlying goal-directed behaviour, namely action selection and initiation through event binding and conflict adaptation. We also investigated whether individual differences in the magnitude of medication effects were associated across these processes. Results showed no indications that dopaminergic medication affects action selection and initiation or conflict adaptation in PD patients. Additionally, we observed no correlations between both cognitive processes nor between individual differences in medication effects. Our findings do not support the notion that dopaminergic medication modulates action control processes, suggesting that the dopamine overdose hypothesis may only apply to a specific set of cognitive processes and should potentially be refined.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在行动控制中测试多巴胺过量假说:一项帕金森病患者的研究
先前对帕金森病(PD)患者的研究表明,在PD的早期到中期给予多巴胺能药物有利于与多巴胺耗尽的背纹状体回路相关的(运动)功能,但可能“过量”并干扰与相对完整的腹侧纹状体回路相关的(认知)功能。本研究旨在阐明这种所谓的多巴胺过量的假设在行动控制领域。在13名PD患者的样本中,我们使用受试者内设计,评估了多巴胺能药物对目标导向行为的两个认知过程的影响,即通过事件绑定和冲突适应进行行动选择和启动。我们还调查了在这些过程中,药物作用程度的个体差异是否相关。结果显示,没有迹象表明多巴胺能药物影响PD患者的行动选择和开始或冲突适应。此外,我们没有观察到两种认知过程之间的相关性,也没有观察到药物效果的个体差异。我们的研究结果不支持多巴胺能药物调节动作控制过程的观点,这表明多巴胺过量假说可能只适用于一组特定的认知过程,应该加以改进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Neuropsychology
Journal of Neuropsychology 医学-心理学
CiteScore
4.50
自引率
4.50%
发文量
34
审稿时长
>12 weeks
期刊介绍: The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.
期刊最新文献
Reducing confusion surrounding expert conceptions of Alzheimer's and dementia: A practical analysis. Translation and validation of the abbreviated Prefrontal Symptoms Inventory (PSI-20): A tool for assessing prefrontal symptoms in English-speaking populations. Cognitive assessment: More important than ever. From neuropsychology to embodied neuroscience: Introduction to the special issue on body representation and body transformations. Memory problems in elderly people with traumatic brain injury.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1