Advancing gastric cancer precision medicine with novel genomic screens†

IF 5.6 2区医学 Q1 ONCOLOGY The Journal of Pathology Pub Date : 2022-12-21 DOI:10.1002/path.6046

Nicole B Halmai, Luis G Carvajal-Carmona

引用次数: 0

Abstract

A recent study published in The Journal of Pathology used an shRNA library targeting all known human genes involved in metabolism to identify genes important for gastric cancer. The screen identified aspartyl‐tRNA synthetase (DARS) as a potential drug target, and patients whose tumors had high DARS levels had a worse prognosis, particularly among diffuse‐type gastric cancer. These findings identify a potential therapeutic target for precision medicine of gastric cancer patients, and may be useful for further investigations to discover additional interacting targets. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

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新型基因组筛选技术推进胃癌精准医疗

最近发表在《病理学杂志》上的一项研究使用shRNA文库靶向所有已知的参与新陈代谢的人类基因，以确定对癌症重要的基因。筛选确定天冬氨酰-tRNA合成酶（DARS）是一个潜在的药物靶点，肿瘤DARS水平高的患者预后较差，尤其是在扩散型癌症中。这些发现为癌症患者的精准医学确定了一个潜在的治疗靶点，并可能有助于进一步研究发现其他相互作用的靶点。©2022作者。病理学杂志由John Wiley&；代表大不列颠及爱尔兰病理学会的Sons有限公司。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Journal of Pathology 医学-病理学

CiteScore

14.10

自引率

1.40%

发文量

144

审稿时长

3-8 weeks

期刊介绍： The Journal of Pathology aims to serve as a translational bridge between basic biomedical science and clinical medicine with particular emphasis on, but not restricted to, tissue based studies. The main interests of the Journal lie in publishing studies that further our understanding the pathophysiological and pathogenetic mechanisms of human disease. The Journal of Pathology welcomes investigative studies on human tissues, in vitro and in vivo experimental studies, and investigations based on animal models with a clear relevance to human disease, including transgenic systems. As well as original research papers, the Journal seeks to provide rapid publication in a variety of other formats, including editorials, review articles, commentaries and perspectives and other features, both contributed and solicited.