Recent Advances in the Discovery and Development of Plant-Derived Natural Coumarins and their Analogues as Anti Human Immunodeficiency Virus—Type 1 (HIV-1) Agents

IF 1.4 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology & Biotechnological Equipment Pub Date : 2005-01-01 DOI:10.1080/13102818.2005.10817148
I. Kostova, S. Raleva, P. Genova, R. Argirova
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引用次数: 6

Abstract

ABSTRACT The acquired immunodeficiency syndrome (AIDS) is a result of human immunodeficiency virus (HIV) infection which leads to severe suppression of immune functions. AIDS is a real threat to the health of mankind, and the search for effective therapies is still of great importance. However, besides the high cost, there are adverse effects and limitations associated with chemotherapy applied. Thus, herbal medicines are frequently used as an alternative therapy by individuals living with HIV. Numerous plant-derived compounds have been evaluated for inhibitory effects on HIV replication, and many coumarins have been found to inhibit different steps in HIV replication cycle. The aim of this review is to summarize research findings for herbal medicines, especially coumarins, which are endowed with the ability to inhibit HIV.
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植物源性天然香豆素及其类似物抗人类免疫缺陷病毒1型(HIV-1)药物的发现与开发进展
获得性免疫缺陷综合征(AIDS)是人类免疫缺陷病毒(HIV)感染导致免疫功能严重抑制的结果。艾滋病是对人类健康的真正威胁,寻找有效的治疗方法仍然十分重要。然而,除了成本高外,化疗也有副作用和局限性。因此,草药经常被艾滋病毒感染者用作替代疗法。许多植物源化合物已被评估对HIV复制的抑制作用,许多香豆素已被发现抑制HIV复制周期的不同步骤。本文综述了以香豆素为代表的具有抗HIV能力的中草药的研究进展。
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来源期刊
Biotechnology & Biotechnological Equipment
Biotechnology & Biotechnological Equipment 工程技术-生物工程与应用微生物
CiteScore
3.10
自引率
0.00%
发文量
90
审稿时长
1 months
期刊介绍: Biotechnology & Biotechnological Equipment (B&BE) is an international open access journal publishing cutting-edge research. A modern world requires modern biotechnology and nanobiology. The journal is a forum that provides society with valuable information for a healthy and better life and promotes “the Science and Culture of Nature”. The journal publishes original research and reviews with a multidisciplinary perspective; expanded case reports with a focus on molecular medical research and advanced practice in evidence-based medicine are also considered.
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