Cognitive Function During Vagus Nerve Stimulation for Treatment-Refractory Epilepsy: A Pilot Study Using the Critical Flicker Fusion Test

K. Achinivu, E. Staufenberg, C. Cull, A. Cavanna, H. Ring
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引用次数: 7

Abstract

This pilot study assessed neuro-cognitive functioning in 7 adults treated with Vagus Nerve Stimulation (VNS) for refractory epilepsy over a 12-month period. All patients were assessed using the Critical Flicker Fusion (CFF) test, a sensitive measure of the ability of the central nervous system to discriminate items of sensory information, along with a standardized battery of neuropsychological and behavioral measures. Reduction in seizure frequency and psychiatric ratings was accompanied by a selective but significant (p < .05) improvement in CFF performance. These findings suggest that the CFF test could be a useful indicator of improvement in neurocognitive functioning during VNS.
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迷走神经刺激治疗难治性癫痫期间的认知功能:一项使用临界闪烁融合试验的初步研究
这项初步研究评估了7名接受迷走神经刺激(VNS)治疗顽固性癫痫12个月期间的神经认知功能。所有患者都使用临界闪烁融合(CFF)测试进行评估,这是一种对中枢神经系统区分感觉信息项目能力的敏感测量,以及一组标准化的神经心理学和行为测量。癫痫发作频率和精神病学评分的降低伴随着CFF表现的选择性但显著的改善(p < 0.05)。这些发现表明,CFF测试可能是VNS期间神经认知功能改善的有用指标。
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