Front Cover: Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 Coupling and Domino Cyclization Approach (ChemMedChem 17/2023)

Abstract

The Front Cover depicts a female Anopheles spp. mosquito, the vector of Plasmodium falciparum and perhaps the most iconic image associated with the fight against malaria, which inspects the structure of a new indole scaffold with promising activity against blood-stage malaria parasites, under the moonlight (the vector has a nocturnal feeding habit, where transmission occurs). The highlighted lead compound is rising to the moon and above blood-stage parasitic forms of P. falciparum, in which this new scaffold revealed preferential inhibitory activity. The copyrighted Anopheles picture is used with the permission of Prof. Laurence J. Zwiebel. Cover design by Natália Marques Mota. More information can be found in the Research Article by Gustavo da Silva, Rui Moreira et al.