{"title":"The role of hydrogen sulphide in lung diseases","authors":"C. H. K. Wu","doi":"10.1093/BIOHORIZONS/HZT009","DOIUrl":null,"url":null,"abstract":"Hydrogen sulphide (H2S) is a recently discovered gasotransmitter. It is endogenously synthesized by cystathionine β synthetase, cystathionine γ lyase, cysteine aminotransferase, 3-mercaptopyruvate sulphurtransferase and cysteine lyase. Its metabolism leads to the production of sulphate (SO4 2− ), methanthiol, dimethylsulphide and thiocynate. The gas interacts with ion channels, protein kinases and transcription factors. It is also involved in post-translational modification of proteins via S-sulphhydration. Although debate continues as to whether H2S is pro- or anti-inflammatory, its anti-inflammatory properties seem to have beneficial effects in various lung diseases. Serum levels of H 2S differ between asthma, chronic obstructive pul monary disease and pulmonary fibrosis, which makes it difficult for the gas to be used as a biomarker for lung diseases. Apart from exogenous sources of H2S, targets to enhance or inhibit the gas can be found in its synthesis and metabolism pathway. H2S-releasing non-steroidal anti-inflammatory drugs are currently being developed. Further research will aid to determine the precise role of H2S in respiratory diseases.","PeriodicalId":52095,"journal":{"name":"Bioscience Horizons","volume":"6 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/BIOHORIZONS/HZT009","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioscience Horizons","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/BIOHORIZONS/HZT009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 4
Abstract
Hydrogen sulphide (H2S) is a recently discovered gasotransmitter. It is endogenously synthesized by cystathionine β synthetase, cystathionine γ lyase, cysteine aminotransferase, 3-mercaptopyruvate sulphurtransferase and cysteine lyase. Its metabolism leads to the production of sulphate (SO4 2− ), methanthiol, dimethylsulphide and thiocynate. The gas interacts with ion channels, protein kinases and transcription factors. It is also involved in post-translational modification of proteins via S-sulphhydration. Although debate continues as to whether H2S is pro- or anti-inflammatory, its anti-inflammatory properties seem to have beneficial effects in various lung diseases. Serum levels of H 2S differ between asthma, chronic obstructive pul monary disease and pulmonary fibrosis, which makes it difficult for the gas to be used as a biomarker for lung diseases. Apart from exogenous sources of H2S, targets to enhance or inhibit the gas can be found in its synthesis and metabolism pathway. H2S-releasing non-steroidal anti-inflammatory drugs are currently being developed. Further research will aid to determine the precise role of H2S in respiratory diseases.