Cell therapy for multiple sclerosis: a new hope

Q2 Agricultural and Biological Sciences Bioscience Horizons Pub Date : 2014-01-01 DOI:10.1093/BIOHORIZONS/HZU014
S. Harbison
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引用次数: 2

Abstract

Multiple sclerosis is a chronic demyelinating autoimmune disease with uncertain aetiology. Due to the heterogeneity of the disease, patients may present with a wide variety of neurological symptoms such as optic neuritis, sensory deficits or cerebel lar dysfunction. It remains a disease showing little hope in terms of finding a cure. Although current therapies, such as interferon-β and glatiramer acetate, provide symptomatic relief and can delay the degenerative process, there is still a large impact on quality of life as these therapies lack an ability to reverse damage occurring prior to treatment. Recently, cell therapy has emerged as a promising treatment with signs of recovery both pathologically and clinically in a variety of animal models. Given the multifaceted capabilities of the various stem cells, including immunomodulation and neuroprotection, their potential use as a comprehensive therapy is much more promising than any pharmacological therapy to date. Here, the latest advances of cell therapy are discussed, in terms of potential efficacy, the various cell types that are used, their mecha nisms of action and the obstacles that still need to be overcome for translation into a clinical setting.
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多发性硬化症的细胞疗法:新的希望
多发性硬化是一种病因不明的慢性脱髓鞘性自身免疫性疾病。由于该病的异质性,患者可能出现多种神经系统症状,如视神经炎、感觉缺陷或小脑功能障碍。就找到治疗方法而言,它仍然是一种希望渺茫的疾病。尽管目前的治疗方法,如干扰素-β和醋酸格拉替雷默,可以缓解症状并延缓退行性过程,但由于这些治疗方法缺乏逆转治疗前发生的损伤的能力,仍然对生活质量有很大影响。最近,细胞疗法已经成为一种有希望的治疗方法,在各种动物模型中都有病理和临床恢复的迹象。鉴于各种干细胞的多方面能力,包括免疫调节和神经保护,它们作为综合治疗的潜在用途比迄今为止任何药物治疗都更有希望。在这里,我们讨论了细胞治疗的最新进展,包括潜在的疗效、所使用的各种细胞类型、它们的作用机制以及转化为临床环境仍需要克服的障碍。
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来源期刊
Bioscience Horizons
Bioscience Horizons Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
1.50
自引率
0.00%
发文量
0
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