Investigating the association of mood and fatigue with objective and subjective cognitive impairment in multiple sclerosis

IF 2 4区心理学 Q2 PSYCHOLOGY Journal of Neuropsychology Pub Date : 2022-06-28 DOI:10.1111/jnp.12283

Laura Davenport, Clodagh Cogley, Ruth Monaghan, Maria Gaughan, Mei Yap, Jessica Bramham, Niall Tubridy, Chris McGuigan, Fiadhnait O'Keeffe

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引用次数: 3

Abstract

Discrepancies between subjective cognitive difficulties and objective measures of cognitive function in people with MS have been identified and may be related to mood and fatigue. The aim of the present study was to examine associations of depression and fatigue with discrepancies between subjective and objective cognitive functioning in pwMS. 177 participants with MS attending a University Hospital Department of Neurology MS Outpatient clinic completed the Brief International Cognitive Assessment for MS (BICAMS), MS Neuropsychological Questionnaire (MSNQ), Hospital Anxiety and Depression Scale (HADS) and Modified Fatigue Impact Scale (MFIS). To quantify the discrepancy between objective (BICAMS) and subjective (MSNQ) cognitive functioning, discrepancy scores were calculated by subtracting MSNQ z-score from composite BICAMS z-score. Based on their discrepancy score, participants were grouped as ‘Underestimated’, ‘Overestimated’ and ‘Non-discrepant’. 39% of the total sample demonstrated poorer subjective cognitive functioning than their objective cognitive performance suggested (‘Underestimated’). 23% of the total sample indicated lower objective scores than their subjective report suggests (‘Overestimated’). 38% participants indicated relatively no discrepancy between objective and subjective cognitive measures (‘Non-discrepant’). Significant differences were observed between the discrepancy groups in terms of depression and fatigue, with the ‘Underestimated’ group demonstrating greater levels of depression and fatigue (ps < .01). Regression analysis indicated that cognitive fatigue and depression significantly contributed to variance in subjective cognitive functioning. Our findings suggest that subjective reports of cognitive function may be influenced by depression and fatigue, emphasising the importance of cognitive, mood and fatigue screening as part of routine clinical care.

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调查多发性硬化症患者情绪和疲劳与客观和主观认知障碍的关系

MS患者的主观认知困难和客观认知功能测量之间的差异已经被确定，可能与情绪和疲劳有关。本研究的目的是检查抑郁症和疲劳与主客观认知功能差异的关联。177名MS患者在某大学医院神经内科MS门诊完成了国际MS简短认知评估(BICAMS)、MS神经心理问卷(MSNQ)、医院焦虑抑郁量表(HADS)和修正疲劳影响量表(MFIS)。为了量化客观认知功能(BICAMS)和主观认知功能(MSNQ)之间的差异，用BICAMS z-score减去MSNQ z-score计算差异评分。根据他们的差异得分，参与者被分为“低估”、“高估”和“非差异”。总样本中有39%的人表现出较差的主观认知功能，而不是他们的客观认知表现(“低估”)。总样本中有23%的人的客观得分低于他们的主观报告(“高估”)。38%的参与者表示客观和主观认知测量之间相对没有差异(“无差异”)。在抑郁和疲劳方面，差异组之间观察到显著差异，“低估”组表现出更高水平的抑郁和疲劳(ps < 0.01)。回归分析表明，认知疲劳和抑郁对主观认知功能变异有显著影响。我们的研究结果表明，认知功能的主观报告可能受到抑郁和疲劳的影响，强调了认知、情绪和疲劳筛查作为常规临床护理一部分的重要性。

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来源期刊

Journal of Neuropsychology 医学-心理学

CiteScore

4.50

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.