Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective

IF 10.9 1区医学 Q1 CHEMISTRY, MEDICINAL Medicinal Research Reviews Pub Date : 2021-12-07 DOI:10.1002/med.21873

Jiao Qu, Qianqian Liu, Guoquan You, Ling Ye, Yiguang Jin, Lingdong Kong, Wenjie Guo, Qiang Xu, Yang Sun

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引用次数: 10

Abstract

Andrographolide, a well-known natural lactone having a range of pharmacological actions in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this review, we cover the pharmacokinetics and pharmacological activity of andrographolide which supports its further clinical application in cancers and inflammatory diseases. Growing evidence shows a good therapeutic effect in inflammatory diseases, including liver diseases, joint diseases, respiratory system diseases, nervous system diseases, heart diseases, inflammatory bowel diseases, and inflammatory skin diseases. As a result, the effects of andrographolide on immune cells and the processes that underpin them are discussed. The preclinical use of andrographolide to different organs in response to malignancies such as colorectal, liver, gastric, breast, prostate, lung, and oral cancers has also been reviewed. In addition, several clinical trials of andrographolide in inflammatory diseases and cancers have been summarized. This review highlights recent advances in ameliorating inflammatory diseases as well as cancers by andrographolide and its analogs, providing a new perspective for subsequent research of this traditional natural product.

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穿心莲内酯改善炎症性疾病和癌症的研究进展:药代动力学、药效学和展望

穿心莲内酯，一种著名的天然内酯，在中药中具有一系列药理作用。长期以来，它一直被用来治疗各种疾病。本文就穿心莲内酯的药代动力学和药理活性进行综述，为其在癌症和炎症性疾病中的进一步临床应用提供依据。越来越多的证据表明，它对炎症性疾病有良好的治疗效果，包括肝脏疾病、关节疾病、呼吸系统疾病、神经系统疾病、心脏病、炎症性肠病和炎症性皮肤病。因此，穿心莲内酯对免疫细胞的影响和支持它们的过程进行了讨论。临床前应用穿心莲内酯治疗不同器官的恶性肿瘤，如结直肠癌、肝癌、胃癌、乳腺癌、前列腺癌、肺癌和口腔癌也进行了综述。此外，还对穿心莲内酯治疗炎症性疾病和癌症的临床试验进行了综述。本文综述了穿心莲内酯及其类似物在改善炎症性疾病和癌症方面的最新进展，为这一传统天然产物的后续研究提供了新的视角。

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来源期刊

Medicinal Research Reviews 医学-药学

CiteScore

29.30

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.

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