Spasmolytic polypeptide-expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer

IF 5.6 2区医学 Q1 ONCOLOGY The Journal of Pathology Pub Date : 2023-05-05 DOI:10.1002/path.6089

James R Goldenring

引用次数: 0

Abstract

Intestinal-type gastric cancer arises in a field of precancerous metaplastic lineages. Two types of metaplastic glands are found in the stomachs of humans with the characteristics of pyloric metaplasia or intestinal metaplasia. While spasmolytic polypeptide-expressing metaplasia (SPEM) cell lineages have been identified in both pyloric metaplasia and incomplete intestinal metaplasia, it has been unclear whether SPEM lineages or intestinal lineages can give rise to dysplasia and cancer. A recent article published in The Journal of Pathology describes a patient with evidence of an activating Kras(G12D) mutation in SPEM that is propagated into adenomatous and cancerous lesions which manifest further oncogenic mutations. This case therefore supports the concept that SPEM lineages can serve as a direct precursor for dysplasia and intestinal-type gastric cancer. © 2023 The Pathological Society of Great Britain and Ireland.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Spasmolytic polypeptide-expressing metaplasia (SPEM)细胞系可能是胃癌的起源

肠型癌症起源于癌前化生谱系。在人类的胃中发现了两种类型的化生腺，其特征是幽门化生或肠化生。虽然在幽门化生和不完全肠化生中都已鉴定出痉挛性多肽脱羧化生（SPEM）细胞系，但尚不清楚SPEM细胞系或肠细胞系是否会导致发育不良和癌症。最近发表在《病理学杂志》上的一篇文章描述了一名患者，有证据表明SPEM中存在激活的Kras（G12D）突变，该突变被传播到腺瘤和癌性病变中，这些病变表现出进一步的致癌突变。因此，该病例支持SPEM谱系可以作为发育不良和肠道型癌症的直接前兆的概念。©2023大不列颠及爱尔兰病理学会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

The Journal of Pathology 医学-病理学

CiteScore

14.10

自引率

1.40%

发文量

144

审稿时长

3-8 weeks

期刊介绍： The Journal of Pathology aims to serve as a translational bridge between basic biomedical science and clinical medicine with particular emphasis on, but not restricted to, tissue based studies. The main interests of the Journal lie in publishing studies that further our understanding the pathophysiological and pathogenetic mechanisms of human disease. The Journal of Pathology welcomes investigative studies on human tissues, in vitro and in vivo experimental studies, and investigations based on animal models with a clear relevance to human disease, including transgenic systems. As well as original research papers, the Journal seeks to provide rapid publication in a variety of other formats, including editorials, review articles, commentaries and perspectives and other features, both contributed and solicited.