POSTER SESSION 2: Thursday, 1 May 2008, 13:30–18:00 Location: Poster Area

Abstract

R Mitsutake; S Miura; B Zhang; K Saku Fukuoka University Hospital Cardiology, Fukuoka, Japan Background: A relationship has been noted between lower levels of HDL-associated phospholipid and atherosclerotic coronary artery disease (CAD). The aim of this study was to assess the relationship between numerous lipidemic factors and severity of CAD as evaluated by multi-detector row computed tomography (MDCT). Methods and Results: Subjects included 195 consecutive patients who underwent coronary angiography using MDCT because of suspected CAD. Coronary artery calcification (CAC) score and Gensini’s score (GS) as evaluated by MDCT, platelet-activating factor acetylhydrolase (PAF-AH), free cholesterol (FC), phospholipid (PL), remnant-like lipoprotein particle-cholesterol (RLP-C), apolipoprotein (apo)-C, apo-B, apo-C3, apo-E, highly-sensitive CRP were determined. The number of the significant coronary vessel disease (VD) was determined using MDCT. The number of VD was significantly associated with HDL-C, HDL-associated HDL-C, HDL-associated PL, HDL-associated FC and RLP-C. Logistic regression analysis revealed that the number of VD was most closely correlated with HDL-C levels (p=0.02). GS was significantly associated with age, HDL cholesterol, hemoglobin A1c, HDLassociated PAF-AH, HDL-associated FC and HDL-associated phospholipid. Multivariate analysis revealed that GS was most closely correlated with HDL-associated phospholipid (p=0.02). Conclusion: Lower levels of HDL-associated phospholipid may be an indicator and provide additional information regarding the severity of CAD compared with other lipidemic factors.