Structure, function, and relevance of thyroid peroxidase in inherited diseases of the thyroid

Abstract

Recent advances have been made in the research on structure and function of thyroid peroxidase in the field of the reaction mechanism with respect to the involvement of compound l in iodination and thyroid hormonogenesis. New information has become available concerning the mechanism of thyroid peroxidase autoantibody formation and immunodominant domains on the thyroid peroxidase molecule. In certain types of hereditary congenital hypothyroidism, called total iodide organification defects, thyroid peroxidase is impaired owing to mutations in the thyroid peroxidase gene. Detailed investigations on the proteins expressed in vitro have been described.