{"title":"Does Dose Matter in Intravenous Thrombolysis for Acute Pulmonary Embolism?","authors":"M. Sonnick, D. Zappetti","doi":"10.1097/CPM.0000000000000292","DOIUrl":null,"url":null,"abstract":"Synopsis: In a retrospective analysis of intensive care unit patients using voluntarily reported national data, half-dose intravenous tissue plasminogen activator (tPA) for acute pulmonary embolism increased the need for escalation of care when compared with full-dose intravenous tPA. There was a lower risk of bleeding for halfdose tPA. Source: Kiser TH, Burnham EL, Clark B, et al. Half-dose versus fulldose alteplase for treatment of pulmonary embolism. Crit Care Med. 2018;46(10).","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/CPM.0000000000000292","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Pulmonary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/CPM.0000000000000292","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Synopsis: In a retrospective analysis of intensive care unit patients using voluntarily reported national data, half-dose intravenous tissue plasminogen activator (tPA) for acute pulmonary embolism increased the need for escalation of care when compared with full-dose intravenous tPA. There was a lower risk of bleeding for halfdose tPA. Source: Kiser TH, Burnham EL, Clark B, et al. Half-dose versus fulldose alteplase for treatment of pulmonary embolism. Crit Care Med. 2018;46(10).
摘要:在一项使用自愿报告的国家数据的重症监护病房患者的回顾性分析中，与全剂量静脉注射tPA相比，半剂量静脉注射组织型纤溶酶原激活剂(tPA)治疗急性肺栓塞增加了护理升级的需求。半剂量tPA组出血风险较低。资料来源:Kiser TH, Burnham EL, Clark B等。半剂量与全剂量阿替普酶治疗肺栓塞。危重医学，2018;46(10)。
期刊介绍：
Clinical Pulmonary Medicine provides a forum for the discussion of important new knowledge in the field of pulmonary medicine that is of interest and relevance to the practitioner. This goal is achieved through mini-reviews on focused sub-specialty topics in areas covered within the journal. These areas include: Obstructive Airways Disease; Respiratory Infections; Interstitial, Inflammatory, and Occupational Diseases; Clinical Practice Management; Critical Care/Respiratory Care; Colleagues in Respiratory Medicine; and Topics in Respiratory Medicine.
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