The Prophylactic Use of Macrolide Antibiotics to Prevent Acute Exacerbations in Bronchiectasis

E. Jirru, D. Zappetti
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Abstract

Synopsis: A systematic review and meta-analysis revealed that the use of prophylactic, long-term macrolides reduces the rate of acute exacerbations in patients with bronchiectasis. This is true across many subgroups including in patients with pseudomonal infection for which current guidelines do not recommend the use of macrolides. Source: Chalmers JD, Boersma W, Lonergan M, et al. Long term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis. Lancet Respir Med. 2019;7: 860–869.
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预防性使用大环内酯类抗生素预防支气管扩张急性加重
摘要:一项系统综述和荟萃分析显示,预防性长期大环内酯类药物的使用可降低支气管扩张患者急性加重的发生率。在许多亚组中都是如此,包括假单胞菌感染患者,目前的指南不建议使用大环内酯类药物。资料来源:Chalmers JD, Boersma W, Lonergan M等。长期大环内酯类抗生素治疗成人支气管扩张:个体参与者数据荟萃分析。中华呼吸医学杂志,2019;7:860-869。
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Clinical Pulmonary Medicine
Clinical Pulmonary Medicine Medicine-Critical Care and Intensive Care Medicine
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期刊介绍: Clinical Pulmonary Medicine provides a forum for the discussion of important new knowledge in the field of pulmonary medicine that is of interest and relevance to the practitioner. This goal is achieved through mini-reviews on focused sub-specialty topics in areas covered within the journal. These areas include: Obstructive Airways Disease; Respiratory Infections; Interstitial, Inflammatory, and Occupational Diseases; Clinical Practice Management; Critical Care/Respiratory Care; Colleagues in Respiratory Medicine; and Topics in Respiratory Medicine.
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