Cocaine esterase occurrence in global wastewater microbiomes and potential for biotransformation of novel psychoactive substances

IF 3.6 4区生物学 Q2 ENVIRONMENTAL SCIENCES Environmental Microbiology Reports Pub Date : 2021-11-11 DOI:10.1111/1758-2229.13020

Eduardo G. de Campos, Otávio G. G. de Almeida, Bruno S. De Martinis, Elaine C. P. De Martinis

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Abstract

The analysis of drugs in wastewater for forensic purposes has been constantly increasing and the investigation of the potential interaction between drugs or metabolites and sewage microbiota is important. The results demonstrated that cocaine esterase genes were widely distributed in 1142 global wastewater samples collected from 64 countries and linked to several bacterial species. In addition, in silico predictions indicated that carfentanil, 4F-MDMB-BINACA, 5F-MDMB-PICA, MDMB-4en-PINACA and mitragynine might also undergo microbial hydrolysis, in a similar fashion of cocaine degradation by cocaine esterase. In conclusion, it was demonstrated the microbial potential to hydrolyze drugs of abuse in wastewater environments, contributing to the critical evaluation of potential metabolites as biomarkers for microbial and human transformation of drugs in wastewater.

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可卡因酯酶在全球废水微生物群中的出现和新型精神活性物质生物转化的潜力

用于法医目的的废水药物分析不断增加，对药物或代谢物与污水微生物群之间潜在相互作用的研究非常重要。结果表明，可卡因酯酶基因广泛分布于从64个国家收集的1142份全球废水样本中，并与几种细菌物种有关。此外，计算机预测表明，卡芬太尼、4F-MDMB-BINACA、5F-MDMB-PICA、MDMB-4en-PINACA和米特拉吉宁也可能经历微生物水解，类似于可卡因酯酶降解可卡因的方式。总之，该研究证明了微生物在废水环境中水解滥用药物的潜力，有助于对潜在代谢物作为废水中微生物和人类药物转化的生物标志物进行关键评估。

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来源期刊

Environmental Microbiology Reports ENVIRONMENTAL SCIENCES-MICROBIOLOGY

CiteScore

6.00

自引率

3.00%

发文量

审稿时长

3.0 months

期刊介绍： The journal is identical in scope to Environmental Microbiology, shares the same editorial team and submission site, and will apply the same high level acceptance criteria. The two journals will be mutually supportive and evolve side-by-side. Environmental Microbiology Reports provides a high profile vehicle for publication of the most innovative, original and rigorous research in the field. The scope of the Journal encompasses the diversity of current research on microbial processes in the environment, microbial communities, interactions and evolution and includes, but is not limited to, the following: the structure, activities and communal behaviour of microbial communities microbial community genetics and evolutionary processes microbial symbioses, microbial interactions and interactions with plants, animals and abiotic factors microbes in the tree of life, microbial diversification and evolution population biology and clonal structure microbial metabolic and structural diversity microbial physiology, growth and survival microbes and surfaces, adhesion and biofouling responses to environmental signals and stress factors modelling and theory development pollution microbiology extremophiles and life in extreme and unusual little-explored habitats element cycles and biogeochemical processes, primary and secondary production microbes in a changing world, microbially-influenced global changes evolution and diversity of archaeal and bacterial viruses new technological developments in microbial ecology and evolution, in particular for the study of activities of microbial communities, non-culturable microorganisms and emerging pathogens.