Adhesion of Osteoblast-like Cells (Saos-2) on Micro-/Submicro-Patterned Apatite Scaffolds Fabricated with Apatite Cement Paste by Micro-Molding

Q4 Engineering Nano Biomedicine Pub Date : 2016-12-01 DOI:10.11344/NANO.8.112
T. Akasaka, H. Miyaji, N. Kaga, A. Yokoyama, S. Abe, Y. Yoshida
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引用次数: 6

Abstract

112 Introduction Calcium phosphate materials have been widely used in several medical scaffolds and coatings of dental implants for bone tissue repair and augmentation because of their excellent osteoconductivity and osteoinductivity. Nowadays, calcium phosphate materials have been designed in various forms including nanoparticles, nanofibers, cements, and coatings in tissue engineering [1-3]. Many micro-/nano-structures composed of calcium phosphate, such as bone and teeth in the body, play an important role in bone and teeth architecture [4, 5]. The organization of collagen and hydroxyapatite (HAp) is suggested in bone architecture, where nanohydroxyapatites are oriented to organic collagen fibers and are hierarchically organized with collagen bundles [6, 7]. Dental enamel is a highly organized array of apatite nanocrystals. It is composed of parallel Adhesion of Osteoblast-like Cells (Saos-2) on Micro-/Submicro-Patterned Apatite Scaffolds Fabricated with Apatite Cement Paste by Micro-Molding
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成骨细胞样细胞(Saos-2)在磷灰石水泥浆料微模塑制备的微/亚微图案磷灰石支架上的粘附
磷酸钙材料由于其优异的骨导电性和成骨诱导性,已广泛应用于多种医用支架和牙种植体涂层中,用于骨组织修复和增强。目前,在组织工程中,磷酸钙材料的设计形式多种多样,包括纳米颗粒、纳米纤维、水泥和涂层等[1-3]。磷酸钙组成的许多微/纳米结构,如人体内的骨和牙,在骨和牙的构建中起着重要作用[4,5]。胶原和羟基磷灰石(HAp)的组织在骨结构中被提出,其中纳米羟基磷灰石面向有机胶原纤维,并与胶原束分层组织[6,7]。牙釉质是一种高度有序的磷灰石纳米晶体。它是由成骨细胞样细胞(Saos-2)平行粘附在由磷灰石水泥膏体微模塑制成的微/亚微图案磷灰石支架上组成的
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Nano Biomedicine
Nano Biomedicine Engineering-Biomedical Engineering
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0.30
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