Cyclic adenosine 5'-monophosphate in Escherichia coli.

Abstract

INTRODUCTION ................ ROLE OF CYCLIC AMP IN REGULATION OF GENE EXPRESSION .......... A Positive Element in Gene Expression ...................................... CRP .......................... :........................................... Direct stimulation of gene expression ...................................... Possible Role As a Negative Element ......................................... Does Cyclic AMP Rave Other Actions in E. co .............................. OPERON ACTIVATION BY CYCLIC AMP .................................... Genetic analysis of the lac promoter ....................................... CONTROL OF CYCLIC AMP LEVELS ........................................ Adenylate Cyclase ........................................................... Cyclic AMP Phosphodiesterase ...................................... Cyclic AMP Release ......................................................... Rate of Cyclic AMP Synthesis ............................................... CYCLIC AMP RECEPTOR PROTEIN ........................................ Physical properties of CRP ................................................ Cyclic AMP binding .... Promoter-specific DNAbinding. Effects of cyclic AMP on CRP structure .................................... CYCLIC AMP AND BACTERIOPHAGE A ...................................... CYCLIC GMP ................................................................ CONCLUSION ................................................................ LITERATURE CITED ........................................................