Behcet's Disease: Is There Geographical Variation? A Review Far from the Silk Road

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2015-12-20 DOI:10.1155/2015/945262
Nieves Leonardo, Julian McNeil
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引用次数: 71

Abstract

Behcet's Disease (BD) is a systemic vasculitis characterized by the triad of recurrent mouth and genital ulcers with eye involvement. To date there are no laboratory tests specific for the disease and diagnosis continues to remain on clinical grounds. Multiple criteria have been created as guides for diagnosis; however, given the wide spectrum of organ involvement, some cases remain undiagnosed. The diagnosis of Behcet's Disease may only be made over time as the clinical manifestations emerge sometimes separated by months and even years. With an increased recognition of this disease it has become apparent that there is geographical variation in clinical manifestations. In particular cardiac manifestations are not seen commonly in Caucasians compared to Asian and Middle Eastern patients, while neurological manifestations are more common in Caucasians. Use of immunosuppressive and immunomodulatory drugs to suppress inflammation remains the cornerstone of treatment.
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白塞氏病:是否存在地理差异?远离丝绸之路
白塞氏病(BD)是一种系统性血管炎,其特征是口腔和生殖器溃疡反复发作并累及眼部。迄今为止,还没有针对这种疾病的实验室检测,诊断仍然依靠临床依据。已经制定了多种标准作为诊断指南;然而,由于器官受累范围广,一些病例仍未确诊。白塞病的诊断只能随着时间的推移而做出,因为临床表现有时相隔数月甚至数年。随着对该病认识的增加,临床表现明显存在地域差异。特别是与亚洲和中东患者相比,心脏表现在白种人中并不常见,而神经表现在白种人中更为常见。使用免疫抑制和免疫调节药物来抑制炎症仍然是治疗的基石。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
期刊最新文献
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