Pharmacological Relaxation of the Ureter When Using Ureteral Access Sheaths during Ureterorenoscopy: A Randomized Feasibility Study in a Porcine Model

IF 1.8 Q3 UROLOGY & NEPHROLOGY Advances in Urology Pub Date : 2016-10-20 DOI:10.1155/2016/8064648

S. K. Lildal, K. Andreassen, Frederikke Eichner Christiansen, H. Jung, M. Pedersen, P. Osther

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引用次数: 5

Abstract

Objective. High intraluminal pressure during ureterorenoscopy (URS) increases risk of infectious and haemorrhagic complications. Intrarenal pressure may be reduced by the use of ureteral access sheaths (UASs), which on the other hand may cause ureteral damage. We have previously shown that the β-agonist isoproterenol (ISO), when administered topically in the irrigation fluid, is able to inhibit ureteral muscle tone and lower intrarenal pressure during URS. The aim of this study was to examine the effect of ISO on the success rate of UAS insertion in a porcine model. Materials and Methods. 22 pigs in which a UAS could not initially be placed were randomized to endoluminal irrigation with either ISO (0.1 μg/mL) or saline before a new insertion trial. Subsequently, it was registered whether the UAS could be passed without resistance. During extraction of the sheath, any ureteral lesions were characterized ureteroscopically using the PULS classification system. Surgeons were blinded to randomization. Results. In the ISO group, the observed effect of irrigation was 63% successful UAS insertions, compared to 27% in the saline group. No serious lesions (

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输尿管镜检查中使用输尿管通路鞘时输尿管的药物松弛:猪模型的随机可行性研究

目标。输尿管镜检查(URS)期间的高腔内压增加了感染和出血并发症的风险。使用输尿管通路护套(UASs)可降低肾内压力，但另一方面可能造成输尿管损伤。我们之前已经证明β-激动剂异丙肾上腺素(ISO)，当局部应用于冲洗液时，能够抑制输尿管肌张力和降低尿路尿潴留期间的肾内压。本研究的目的是检验ISO对猪模型中UAS插入成功率的影响。材料和方法:22只最初无法放置UAS的猪随机接受ISO (0.1 μg/mL)或生理盐水的腔内灌洗，然后进行新的插入试验。随后，它被登记是否无人机可以通过无阻力。在拔出鞘时，输尿管病变采用输尿管镜下的PULS分类系统。外科医生对随机分组不知情。结果。在ISO组中，观察到冲洗效果为63%成功插入UAS，而生理盐水组为27%。ISO组未见严重病变(

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来源期刊

Advances in Urology UROLOGY & NEPHROLOGY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Urology is a peer-reviewed, open access journal that publishes state-of-the-art reviews and original research papers of wide interest in all fields of urology. The journal strives to provide publication of important manuscripts to the widest possible audience worldwide, without the constraints of expensive, hard-to-access, traditional bound journals. Advances in Urology is designed to improve publication access of both well-established urologic scientists and less well-established writers, by allowing interested scientists worldwide to participate fully.