{"title":"PRODUCT FOCUS: Analytical and Preparative Instrumentation","authors":"","doi":"10.1177/10870571070120071301","DOIUrl":null,"url":null,"abstract":"profiling (RAP) technology, RAP id 4 enables real-time, label-free measurement and analysis of biomolecular interactions. RAP measures the oscillation of a resonating quartz crystal, which decreases in proportion to the mass of the molecules binding to its surface. Proprietary electronics and algorithms generate measurements, which provide binding information on biomolecular interactions. RAP measures materials that physically bind to the crystal and is unaffected by solvents. Researchers interrogate and evaluate the data using RAP id workbench software. The system is flow based and generates kinetic, affinity, and concentration measurements from mixtures such as cell culture supernatants and periplasmic extracts. A stand-alone automated platform, RAP id 4 typically processes an average of 400 samples per day. For further information, visit www.akubio.com.","PeriodicalId":15087,"journal":{"name":"Journal of Biomolecular Screening","volume":"12 1","pages":"1012 - 1018"},"PeriodicalIF":0.0000,"publicationDate":"2007-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/10870571070120071301","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomolecular Screening","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/10870571070120071301","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0
Abstract
profiling (RAP) technology, RAP id 4 enables real-time, label-free measurement and analysis of biomolecular interactions. RAP measures the oscillation of a resonating quartz crystal, which decreases in proportion to the mass of the molecules binding to its surface. Proprietary electronics and algorithms generate measurements, which provide binding information on biomolecular interactions. RAP measures materials that physically bind to the crystal and is unaffected by solvents. Researchers interrogate and evaluate the data using RAP id workbench software. The system is flow based and generates kinetic, affinity, and concentration measurements from mixtures such as cell culture supernatants and periplasmic extracts. A stand-alone automated platform, RAP id 4 typically processes an average of 400 samples per day. For further information, visit www.akubio.com.
分析(RAP)技术，RAP id 4能够实时、无标签地测量和分析生物分子相互作用。RAP测量谐振石英晶体的振荡，这种振荡与结合在其表面的分子质量成比例地减少。专有的电子和算法产生测量，提供生物分子相互作用的结合信息。RAP测量与晶体物理结合且不受溶剂影响的材料。研究人员使用RAP id工作台软件对数据进行查询和评估。该系统以流动为基础，从细胞培养上清和质周萃取物等混合物中产生动力学、亲和力和浓度测量。作为一个独立的自动化平台，RAP id 4通常每天平均处理400个样品。欲了解更多信息，请访问www.akubio.com。
期刊介绍：
Advancing the Science of Drug Discovery: SLAS Discovery reports how scientists develop and utilize novel technologies and/or approaches to provide and characterize chemical and biological tools to understand and treat human disease.
SLAS Discovery is a peer-reviewed journal that publishes scientific reports that enable and improve target validation, evaluate current drug discovery technologies, provide novel research tools, and incorporate research approaches that enhance depth of knowledge and drug discovery success.
SLAS Discovery emphasizes scientific and technical advances in target identification/validation (including chemical probes, RNA silencing, gene editing technologies); biomarker discovery; assay development; virtual, medium- or high-throughput screening (biochemical and biological, biophysical, phenotypic, toxicological, ADME); lead generation/optimization; chemical biology; and informatics (data analysis, image analysis, statistics, bio- and chemo-informatics). Review articles on target biology, new paradigms in drug discovery and advances in drug discovery technologies.
SLAS Discovery is of particular interest to those involved in analytical chemistry, applied microbiology, automation, biochemistry, bioengineering, biomedical optics, biotechnology, bioinformatics, cell biology, DNA science and technology, genetics, information technology, medicinal chemistry, molecular biology, natural products chemistry, organic chemistry, pharmacology, spectroscopy, and toxicology.
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