Poster Session III: Basic science: translational science

Abstract

P408 Coronary heart disease with depression and studies of serum interleukin-6 level G Maimaitiming First Affiliated Hospital of Xinjiang Medical University, Urumqi, People’s Republic of China Topic: Behavioural medicine Objectives:This study was conducted to explore the relationship between interleukin 6(IL-6) and coronary heart disease with depression, and sought prognostic role of IL-6,in order to come up with intervention strategy on treating coronary heart disease patients who were developed depression. Methods :90 patients with coronary heart disease were recruited into our study,according to ZUNG self depression scale (SDS) score,subjects were divided into two groups as, coronary heart disease with depression (group A) and coronary heart disease without depression (group B ). Results: 57.78% of subjects had varying degree of depression, patients with mild depression were 24 (26.67 %), patients with moderate and severe depression were 28(31.11%); 57.59% of male patients had depression, and 57.89% of female patients had depression, there was no statistical difference between two genders when compare the concomitance rate of depression (P< 0.05); The levels of serum IL-6 in the A group [M(P25, P75)] were [0.04(0.01, 0.06)] ng/ml, B group were[0.02(0.01,0.05)]ng/ml, group A were significantly higher than the B group (P<0.05);In the group A, the levels of serum IL-6 patients with moderate and severe depression were [0.05(0.02,0.08)]ng/ml higher than in patients with mild depression [0.04(0.01,0.05)]ng/ml, (P<0.05);In the group A the serum IL-6 levels was positively correlated with cholesterol?lowdensity lipoprotein?C-reactive protein and left ventricular internal diameter at the end diastolic left ventricular internal diameter (P<0.05), negatively correlated with left ventricular ejection fraction (P<0.05), there was no obvious correlation with triglyceride and high-density lipoproteins. In the group B the serum IL-6 levels was not obviously correlated to cholesterol?triglyceride?low-density lipoprotein?high-density lipoproteins, C-reactive protein, left ventricular internal diameter at the end-diastolic and left ventricular ejection. fraction. Conclusion: The concomitance rate of depression in the coronary heart disease patients were higher, the level of serum inflammatory markers in coronary heart disease patients with depression were higher than coronary heart disease patients without depression; In moderate to severe depressed patients with higher levels of inflammatory markers than in mild depression patients. Depression is a sign of activation of inflammatory responses; inflammatory responses play invariably role in coronary heart disease with depression.