Poster Session II: Basic science: cardiovascular physiology

Abstract

P252 Peculiarities of left ventricular remodeling in subjects with masking arterial hypertension I Osipova, O Antropova, A Zalzman, N Lobanova, K Golovina Altay State Medical University, Barnaul, Russian Federation, Departmental Clinical Hospital, Barnaul, Russian Federation Topic: Early detection of asymptomatic disease The purpose of the study was to estimate target-organs condition in patients with masking (isolated ambulatory) hypertension having operator professions. 329 males were included in the study. According to blood pressure monitoring during working and rest hours the subjects were distributed into 2 groups. 197 patients with masking arterial hypertension at working place formed the 1st group, 132 males with low-stress work and essential hypertension formed the second group. All subjects were performed echocardiography, duplex scanning of brachiocephal arteries. In comparison with 2nd group subjects, 1st group subjects had lower early diastolic filling rate (peak E) over 9.5% (pU0,001) and higher late diastolic filling rate (peak A) over 19.1% (pU0,001), less ratio E/A over 33.3% (pU0,001).Type I diastolic dysfunction was revealed in 147 (74.6%) and 79 (59.8%) subjects of the 1st and 2nd groups correspondingly, that is over 14.8% (XU8.0, pU0,005) more frequent in males with masking arterial hypertension. Left ventricular (LV) hypertrophy was revealed in 75 (38.1%) and 37 (28.1%) subjects of 1 and 2 group correspondingly, thus its frequency was comparable. In 1st group subjects normal LV geometry was detected in 72 (36.5%) subjects, concentric remodeling in 50 (25.4%) subjects, concentric LV hypertrophy 48 (24.4%) subjects, eccentric LV hypertrophy was detected in 27 (13.7%) subjects. In 2nd group subjects normal LV geometry was detected in 59 (44.7%) subjects, concentric remodeling in 36 (27.3%) subjects, concentric LV hypertrophy 16 (12.1%) subjects, eccentric LV hypertrophy was detected in 12.3% subjects (XU7.9; pU0.05). Consequently, in comparison with patients with essential hypertension the patients with masking arterial hypertension have more frequent LV diastolic dysfunction, comparable frequency of LV hypertrophy but its more adverse concentric type.