The correlation between Aflatoxin B1 and Placental Apoptosis in Pregnant women with Intrauterine Growth Restriction

A. Abbas, M. El-Baz, O. Shaaban, Khalid M. Mohany, Thorya S. El-Deeb, Amira M. El-Noweihi
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Abstract

Objective :  Egypt has one of the highest incidences of intrauterine fetal growth restriction (IUGR) around the world. In the current study, we tried to explore the effect of Aflatoxin B1 toxicity as a risk factor of IUGR and to determine the role of placental apoptotic indices in the pathogenesis of IUGR and their association with maternal risk factors as residency, working and exposure to smoking. Materials and Methods :  A case-control study was done at Women Health Hospital; Assiut University, Egypt included 60 pregnant women with asymmetrical IUGR besides a control group of 40 normal pregnancies were selected. Maternal urine samples were obtained for measuring Aflatoxin B1 level by layer chromatography. Quantitative determination of human placental Bcl-2 and caspase-3 using a monoclonal antibody-based enzyme-linked immunosorbent assay kits were performed. Results : The results showed that aflatoxin B1 positive cases in the IUGR group had significantly higher placental caspase-3 and lower placental Bcl-2 concentrations than those which were aflatoxin B1 negative (p<0.01). The levels of placental apoptotic indices were higher in working women who lived in urban areas and those exposed to cigarette smoke than non-working women who lived in rural areas and non-smokers. Conclusions : Aflatoxin B1 may affect the fetal growth by increasing the placental apoptosis. These results may highlight the importance of aflatoxin B1 which may contribute to the complex etiology of IUGR. Placental apoptotic indices levels were significantly affected by maternal residency, working and exposure to smoking in pregnancies complicated with IUGR.
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黄曲霉毒素B1与宫内生长受限孕妇胎盘凋亡的关系
目的:埃及是世界上宫内胎儿生长受限(IUGR)发病率最高的国家之一。在本研究中,我们试图探讨黄曲霉毒素B1毒性作为IUGR的危险因素的作用,并确定胎盘凋亡指标在IUGR发病中的作用及其与母亲居住、工作和吸烟等危险因素的关系。材料与方法:在妇女保健医院进行病例对照研究;埃及Assiut大学选取60名IUGR不对称孕妇作为对照组,另外选取40名正常孕妇作为对照组。取产妇尿液样品,用层析法测定黄曲霉毒素B1水平。采用基于单克隆抗体的酶联免疫吸附测定试剂盒定量测定人胎盘Bcl-2和caspase-3。结果:与黄曲霉毒素B1阴性组相比,IUGR组黄曲霉毒素B1阳性组胎盘caspase-3显著升高,胎盘Bcl-2显著降低(p<0.01)。居住在城市地区的职业妇女和吸烟妇女的胎盘凋亡指数水平高于居住在农村地区的非职业妇女和不吸烟妇女。结论:黄曲霉毒素B1可能通过增加胎盘细胞凋亡影响胎儿生长。这些结果可能强调黄曲霉毒素B1的重要性,它可能导致IUGR的复杂病因。妊娠合并IUGR时,产妇居住、工作和吸烟对胎盘凋亡指数水平有显著影响。
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来源期刊
Thai Journal of Obstetrics and Gynaecology
Thai Journal of Obstetrics and Gynaecology Medicine-Obstetrics and Gynecology
CiteScore
0.40
自引率
0.00%
发文量
3
审稿时长
24 weeks
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