Calcium transport and sensing in TRPC channels – New insights into a complex feedback regulation

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2023-10-18 DOI:10.1016/j.ceca.2023.102816
Jasmin Baron, Klaus Groschner, Oleksandra Tiapko
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Abstract

Canonical TRP (TRPC) channels are a still enigmatic family of signaling molecules with multimodal sensing features. These channels enable Ca2+ influx through the plasma membrane to control a diverse range of cellular functions. Based on both regulatory- and recently uncovered structural features, TRPC channels are considered to coordinate Ca2+ and other divalent cations not only within the permeation path but also at additional sensory sites. Analysis of TRPC structures by cryo-EM identified multiple regulatory ion binding pockets. With this review, we aim at an overview and a critical discussion of the current concepts of divalent sensing by TRPC channels.

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钙在TRPC通道中的转运和传感-对复杂反馈调节的新见解。
典型TRP(TRPC)通道是一个仍然神秘的具有多峰传感特征的信号分子家族。这些通道使Ca2+能够通过质膜流入,以控制各种细胞功能。基于调节和最近未发现的结构特征,TRPC通道被认为不仅在渗透路径内,而且在额外的感觉位点协调Ca2+和其他二价阳离子。通过冷冻电镜对TRPC结构的分析确定了多个调节性离子结合口袋。通过这篇综述,我们旨在对TRPC通道二价传感的当前概念进行概述和批判性讨论。
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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