Simplified assessment for chemical exchanged saturation transfer (CEST) imaging: local offset frequency and CEST effect.

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-10-28 DOI:10.1007/s12194-023-00752-z
Daiki Chiba, Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Hiroaki Hayashi, Akihiro Haga
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Abstract

The aim of this study is to develop a novel phantom for the evaluation of clinical CEST imaging settings, e.g., B0 and B1 field inhomogeneities, CEST contrast, and post-processing. We made a phantom composed of two slice sections: a grid section for local offset frequency evaluation and a sample section for CEST effect evaluation using different concentrations of an egg white albumin solution. On a 3 Tesla MR scanner, a phantom study was performed using CEST imaging; the mean B1 amplitudes were set at 1.2 and 1.9 µT, and CEST images with and without B0 corrections were acquired. Next, region of interest (ROI) analysis was performed for each slice. Then, CEST images with and without B0 corrections were compared at each B1 amplitude. The B0 corrected Z-spectrums at each local region in the grid section showed a shifting of the curve bottom to 0 ppm. Z-spectrum at B1 = 1.9 µT showed a broader curve shape than that at 1.2 µT. Moreover, MTRasym values at 3.5 ppm for each albumin sample at B1 = 1.9 µT were about two times higher than those at 1.2 µT. Our phantom enabled us to evaluate and optimize B0 inhomogeneity and the CEST effect at the B1 amplitude.

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化学交换饱和转移(CEST)成像的简化评估:局部偏移频率和CEST效应。
本研究的目的是开发一种新的体模,用于评估临床CEST成像设置,例如B0和B1场不均匀性、CEST对比度和后处理。我们制作了一个由两个切片组成的体模:一个用于局部偏移频率评估的网格部分和一个用于使用不同浓度的蛋清白蛋白溶液评估CEST效果的样本部分。在3特斯拉MR扫描仪上,使用CEST成像进行体模研究;将平均B1振幅设置为1.2和1.9µT,并采集具有和不具有B0校正的CEST图像。接下来,对每个切片进行感兴趣区域(ROI)分析。然后,在每个B1幅度处比较具有和不具有B0校正的CEST图像。在网格部分中的每个局部区域处的B0校正的Z光谱显示出曲线底部向0ppm的偏移。B1处的Z光谱 = 1.9µT的曲线形状比1.2µT的更宽。此外,B1的每个白蛋白样品在3.5ppm时的MTRasym值 = 1.9µT大约是1.2µT时的两倍。我们的体模使我们能够评估和优化B0的不均匀性以及B1振幅下的CEST效应。
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来源期刊
Radiological Physics and Technology
Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
12.50%
发文量
40
期刊介绍: The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.
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