Alexander Slawik, James B. Silva, Kevin C. Axelrod, J. Urban, N. Platt
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引用次数: 0
Abstract
The US Defence Threat Reduction Agency (DTRA) sponsored a two-year set of experiments, conducted in 2012 and 2013, that were designed and executed by the US Army's Edgewood Chemical and Biological Center (ECBC) and the Naval Medical Research Unit Dayton (NAMRU-D) to explore time-varying inhalation exposures of hydrogen cyanide gas on rats. Our analysis, detailed in a separate paper, finds that a single set of fitted parameters for the toxic load model (i.e., the toxic load exponent n, probit slope m, and median lethal exposure TL50) cannot accurately model the single exposure experimental data across the experiments' full range of time from 2.3 to 30 minutes but can on the longer timescales of 10 to 30 minutes. However, none of the toxic load models that we considered fits the experimental data for the novel, time-varying exposures well, with the average concentration and Griffiths-Megson models providing the least inaccurate casualty predictions.
期刊介绍:
IJEP provides an international forum in the field of environment and pollution and addresses early and medium-term challenges involving scientific prediction, modelling and assessment. It focuses on ground-breaking research in the science of environmental pollution, at the early scientific stage. It is one of three key journals which together offer complete coverage of environmental issues: IJETM focuses on technical/engineering, policy and management solutions for environmental problems, and IJGEnvI focuses on future, longer-term environmental scenarios, ecological economics, climate change and biodiversity.