{"title":"A Data Set to Verify Volume and Sample Removal Correction Calculations for Dissolution Testing","authors":"Alger D. Salt","doi":"10.14227/DT280221P16","DOIUrl":null,"url":null,"abstract":"Software in the form of a spreadsheet, computer program, or web-based application is typically used to perform the appropriate mathematical corrections to dissolution profile data to correct for the amount of sample solution removed from the dissolution vessels at each time interval. Because the sample solutions contain analyte and because removal changes the volume of dissolution medium remaining in the vessels, such corrections are sometimes necessary to determine accurate values. This article presents results from a mental exercise where a theoretical dissolution profile was constructed. These data can be used to verify the accuracy of such calculations.","PeriodicalId":11380,"journal":{"name":"Dissolution Technologies","volume":"28 1","pages":"16-20"},"PeriodicalIF":1.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dissolution Technologies","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14227/DT280221P16","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 1
Abstract
Software in the form of a spreadsheet, computer program, or web-based application is typically used to perform the appropriate mathematical corrections to dissolution profile data to correct for the amount of sample solution removed from the dissolution vessels at each time interval. Because the sample solutions contain analyte and because removal changes the volume of dissolution medium remaining in the vessels, such corrections are sometimes necessary to determine accurate values. This article presents results from a mental exercise where a theoretical dissolution profile was constructed. These data can be used to verify the accuracy of such calculations.
期刊介绍：
Dissolution Technologies is a peer reviewed quarterly
publication reporting ongoing, useful information on
dissolution testing of pharmaceuticals. It provides an
international forum for dissolution analysts to receive
and exchange information on various dissolution topics.
Dissolution Technologies welcomes submissions related
to dissolution, in vitro release, and disintegration testing.
These topics should be the major focus of the article.
Do not submit articles where the focus is formulation
development with dissolution testing as one of many
tests.
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