Cognitive/Clinical Endpoints for Pre-Dementia AD Trials

IF 8.5 3区 医学 Q1 CLINICAL NEUROLOGY Jpad-Journal of Prevention of Alzheimers Disease Pub Date : 2015-01-01 DOI:10.14283/JPAD.2015.62
Aisen Ps
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引用次数: 9

Abstract

With the aging of the world's population, the prevalence of Alzheimer's disease (AD) is rising. Yet it remains the only leading cause of death for which there is no disease-modifying treatment available, despite substantial academic and industry efforts. Disappointing clinical trials over the last several years have led to a growing consensus on the need to intervene early in the disease process, before clinical symptoms begin (1). Built on the hypothetical model of disease progression proposed by Jack et al (2, 3), which has since been supported by empirical data (4), the dominant paradigm today posits that the pathophysiologic processes underlying AD begin long before symptoms (5). However drug development at this stage is complicated by the difficulty of assessing a therapeutic benefit in subjects who are, by definition, clinically normal.
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痴呆前AD试验的认知/临床终点
随着世界人口的老龄化,阿尔茨海默病(AD)的患病率正在上升。然而,尽管学术界和工业界做出了大量努力,但它仍然是唯一没有改善疾病治疗方法的主要死亡原因。过去几年令人失望的临床试验导致越来越多的人认为需要在疾病过程的早期进行干预,在临床症状出现之前(1)。基于Jack等人提出的疾病进展的假设模型(2,3),该模型已经得到了经验数据的支持(4),目前的主流范式认为,阿尔茨海默病的病理生理过程早在症状出现之前就开始了(5)。然而,由于难以评估临床正常受试者的治疗效果,这一阶段的药物开发变得复杂。
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来源期刊
自引率
7.80%
发文量
85
期刊介绍: The JPAD « Journal of Prevention of Alzheimer’Disease » will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including : neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes. JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.
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