Cognitive Performance and Incident Alzheimer's Dementia in Men Versus Women.

IF 8.5 3区医学 Q1 CLINICAL NEUROLOGY Jpad-Journal of Prevention of Alzheimers Disease Pub Date : 2024-01-01 DOI:10.14283/jpad.2023.90

I Liampas, V Siokas, C G Lyketsos, E Dardiotis

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Abstract

Background: The utility of neuropsychological measurements as forerunners of Alzheimer's Disease Dementia (AD) in individuals with normal cognition or mild cognitive impairment (MCI) is undeniable.

Objectives: To assess the differential prognostic value of cognitive performance in older men versus women.

Design: Longitudinal analysis of data acquired from the National Alzheimer's Coordinating Center Uniform Data Set.

Settings: Data on older adults (≥60 years) were derived from 43 National Institute on Aging - funded Alzheimer's Disease Research Centers.

Participants: 10,073 cognitively unimpaired (CU) older adults followed for 5.5±3.8 years and 3,925 participants with amnestic MCI monitored for 3.5±2.8 years.

Measurements: The domains of episodic memory, verbal fluency, naming, attention, processing speed and executive function were assessed. Cox proportional hazards models examined associations between individual cognitive domains and AD incidence separately for each participant set. CU and MCI. These predictive models featured individual neuropsychological measures, sex, neuropsychological measure by sex interactions, as well as a number of crucial covariates.

Results: Episodic memory and verbal fluency were differentially related to future AD among CU individuals, explaining a larger proportion of risk variance in women compared to men. On the other hand, naming, attention and executive function were differentially related to future AD among participants with MCI, accounting for a greater fraction of risk variance in men than women.

Conclusion: Cognitive performance is differentially related to risk of progressing to AD in men versus women without dementia.

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男性与女性的认知能力和阿尔茨海默氏症痴呆症发病率。

背景：神经心理学测量作为阿尔茨海默病痴呆症（AD）的先兆，对认知正常或轻度认知障碍（MCI）患者的作用是毋庸置疑的：评估老年男性与老年女性认知能力的不同预后价值：设计：对从国家阿尔茨海默氏症协调中心统一数据集获得的数据进行纵向分析：老年人（≥60 岁）的数据来自 43 个国家老龄化研究所资助的阿尔茨海默病研究中心：10,073名认知功能未受损（CU）的老年人接受了5.5±3.8年的随访，3,925名患有失忆性MCI的参与者接受了3.5±2.8年的监测：测量方法：对外显记忆、语言流畅性、命名、注意力、处理速度和执行功能进行评估。Cox比例危险模型分别检验了每组参与者的各个认知领域与AD发病率之间的关系。CU和MCI。这些预测模型包括单个神经心理测量指标、性别、神经心理测量指标与性别之间的交互作用以及一些重要的协变量：结果：外显记忆和言语流畅性与CU个体未来的注意力缺失症有不同的关系，与男性相比，女性在风险变异中所占的比例更大。另一方面，在患有 MCI 的参与者中，命名、注意力和执行功能与未来注意力缺失症的关系存在差异，男性在风险变异中所占的比例大于女性：结论：男性和女性的认知能力与发展为老年痴呆症的风险存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jpad-Journal of Prevention of Alzheimers Disease CLINICAL NEUROLOGY-

自引率

7.80%

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期刊介绍： The JPAD « Journal of Prevention of Alzheimer’Disease » will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including : neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes. JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.