Observation and Proposed Measurements of Three-dimensional Tortuous Capillary Pores with Depth for Hollow Fiber Hemoconcentrator Membrane Using Dynamic Force Microscopy

IF 0.8 Q4 ENGINEERING, BIOMEDICAL Advanced Biomedical Engineering Pub Date : 2019-01-01 DOI:10.14326/ABE.8.145
M. Fukuda, Hitoshi Saomoto, Taisei Shimizu, K. Namekawa, K. Sakai
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引用次数: 2

Abstract

A hemoconcentrator is installed as a part of cardiopulmonary bypass to concentrate the blood by removing excess water and unnecessary electrolytes from the blood diluted with myocardial protection uid. The hemoconcentrator must remove water from diluted blood ef ciently and quickly and remove proin ammatory cytokines and other unwanted molecules, without losing useful proteins such as albumin. Especially, the pore diameter and diameter distribution of the innermost surface greatly affect the pure water permeability and sieving coef cient of the solutes. In this study, the pore structure of the inner surface of the membrane was observed, and pore measurement of hollow ber hemoconcentrator membranes was attempted using a scanning probe microscope (SPM). The samples studied were commercially available hemoconcentrator membranes PUREMA A and B (JMS Co. Ltd., Japan) having asymmetric structures. A SPM was used using the dynamic force microscopy (DFM), cyclic contact mode. The deep and tortuous pore structure on the inner surface of the hemoconcentrator membrane was observed for the rst time using DFM. The pores had an elliptical shape, elongated in the longitudinal direction. When the elliptical area on the inner surface of the hemoconcentrator membrane was larger, pure water permeability was higher, showing a correlation between the elliptical area and membrane functions. The mean major pore diameters and minor pore diameters as well as the equivalent pore diameter calculated from the tortuous capillary pore model were consistent. Using DFM, the three-dimensional tortuous capillary pores at the inner surface of a hollow ber hemoconcentrator membrane could be studied, and pore diameter and distribution could be measured by image analysis. The results were supported by the tortuous capillary pore model. In the future, we need to clearly show the further superior innovations or creative/ ingenious techniques related to this study. Further the state of new ndings which contribute to development of a new hemoconcentrator and other semipermeable membranes will help to increase the value of this paper. This study is one of the key studies to achieve the targeted function for the transport phenomena through semipermeable membranes including hemoconcentrator.
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动态力显微镜对中空纤维血液浓缩器膜三维弯曲毛细孔深度的观察及测量建议
血液浓缩器是体外循环的一部分,通过将血液中多余的水和不必要的电解质从心肌保护液稀释后的血液中去除,来浓缩血液。血液浓缩器必须有效、快速地从稀释后的血液中去除水分,去除原蛋白、炎性细胞因子和其他不需要的分子,同时不损失有用的蛋白质,如白蛋白。其中最内层表面的孔径和直径分布对溶质的纯水渗透性和过筛系数影响较大。在本研究中,我们观察了膜内表面的孔隙结构,并尝试使用扫描探针显微镜(SPM)测量空心血液浓缩器膜的孔隙。所研究的样品是市售的具有不对称结构的血液浓缩器膜PUREMA和B(日本JMS公司)。采用动态力显微镜(DFM),采用循环接触模式。DFM首次观察到血液浓缩器膜内表面的深而弯曲的孔隙结构。气孔呈椭圆形,纵向呈细长状。当凝血器膜内表面椭圆面积越大,纯水通透性越高,表明椭圆面积与膜功能之间存在相关性。弯曲毛细管孔隙模型计算的平均大孔径和小孔径及等效孔径基本一致。利用DFM技术,可以研究中空血液浓缩器膜内表面的三维弯曲毛细孔,并通过图像分析测量孔径和分布。结果得到了扭曲毛细管孔隙模型的支持。在未来,我们需要清楚地展示与这项研究相关的进一步的卓越创新或创造性/巧妙的技术。此外,对开发新型凝血剂和其他半透膜的新发现将有助于增加本文的价值。本研究是实现包括凝血器在内的半透膜转运现象靶向功能的关键研究之一。
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来源期刊
Advanced Biomedical Engineering
Advanced Biomedical Engineering ENGINEERING, BIOMEDICAL-
CiteScore
1.40
自引率
10.00%
发文量
15
审稿时长
15 weeks
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