Major sickle cell disease and pregnancy: about 24 cases observed in a reference structure in Senegal (National hospital of pikine)

Abstract

Sickle cell disease is a genotypic condition characterized by the presence of a hemoglobin S which results biologically and clinically suckling red blood cells and hemolytic anemia.1,2 The occurrence of pregnancy in this fragile situation can trigger fearsome maternal and fetal complications even when appropriate preventive measures are used. Management must be multidisciplinary, involving obstetrician, hematologist and pediatrician assisted by different specialists depending on the evolution. Progress in these areas has allowed women to reach reproductive age and even pregnancy with the risk of complications for them and their fetus. For this, early detection of the disease is essential to plan the best time to be pregnant. In view of this context of pregnancy, which deserves great attention, we have decided to conduct a study on the association of major sickle cell disease and pregnancy at the Pikine National Hospital Center. The main objective is to study the management and prognosis of this particularly morbid pathology when it is associated with pregnancy, in the quest to propose a protocol for its management. Patients and methods