CORRELATION OF SERUM LIPID PROFILE, SERUM CALCIUM, ALKALINE PHOSPHATASE AND SERUM PROTEIN WITH HISTOPATHOLOGICAL GRADING AND STAGING IN HEAD AND NECK CANCER

Neha Banseria Neha Banseria, Reeni Malik Reeni Malik, R. Nigam, Trichal V K, A. Shrivastava, Rubal Jain, S. Gupta
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引用次数: 8

Abstract

Lipids have a key role in the maintenance of cell integrity. Hypolipidemia is related with increased risk of cancer and mortality. Elevated calcium and alkaline phosphatase has also been seen in cancer patients having metastasis. Alteration in serum proteins also has been reported. Hence present study was undertaken in 100 histopathologically confirmed head and neck cancer patients, in Department of Pathology Gandhi Medical College Bhopal, after taking informed written consent and ethical clearance. Lipid Profile, Serum Calcium, Alkaline Phosphatase, Serum Protein with Albumin were estimated and compared with age and sex matched healthy controls. Statistical analysis was done using chi square test. Total cholesterol (TC), high density lipoprotein-cholesterol (HDLC), low density lipoprotein-cholesterol (LDLC), Very low density lipoprotein- cholesterol (VLDLC) all decreased in head & neck cancer patients. Hypercalcemia was seen in 35% of patients. Raised Alkaline phosphatase (ALP) was seen in 8 % cancer patients. Serum calcium was found to be increasing with advancing stage. Further studies should be carried out in large number of patients to confirm the role of these parameters with special attention to modifiable ones and their relation with staging and grading of cancer, which can be used as prognostic markers.
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头颈癌患者血脂、血钙、碱性磷酸酶和血清蛋白与组织病理学分级和分期的关系
脂质在维持细胞完整性方面起着关键作用。低血脂与癌症和死亡率的增加有关。钙和碱性磷酸酶升高也见于有转移的癌症患者。血清蛋白的改变也有报道。因此,本研究在博帕尔甘地医学院病理学系进行,在获得知情书面同意和道德许可后,对100名经组织病理学证实的头颈癌患者进行了研究。评估血脂、血清钙、碱性磷酸酶、血清蛋白与白蛋白,并与年龄和性别匹配的健康对照进行比较。统计学分析采用卡方检验。头颈癌患者总胆固醇(TC)、高密度脂蛋白-胆固醇(HDLC)、低密度脂蛋白-胆固醇(LDLC)、极低密度脂蛋白-胆固醇(VLDLC)均下降。35%的患者出现高钙血症。8%的癌症患者碱性磷酸酶(ALP)升高。血清钙随病程进展而升高。进一步的研究需要在大量的患者中进行,以确认这些参数的作用,特别要注意可修改的参数及其与癌症分期和分级的关系,这些参数可以作为预后指标。
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