PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies

IF 6.4 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Current Pollution Reports Pub Date : 2023-06-29 DOI:10.1007/s40726-023-00269-4
Sandra India-Aldana, Meizhen Yao, Vishal Midya, Elena Colicino, Leda Chatzi, Jaime Chu, Chris Gennings, Dean P. Jones, Ruth J. F. Loos, Veronica W. Setiawan, Mathew Ryan Smith, Ryan W. Walker, Dinesh Barupal, Douglas I. Walker, Damaskini Valvi
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Abstract

Purpose of Review

There is a growing interest in understanding the health effects of exposure to per- and polyfluoroalkyl substances (PFAS) through the study of the human metabolome. In this systematic review, we aimed to identify consistent findings between PFAS and metabolomic signatures. We conducted a search matching specific keywords that was independently reviewed by two authors on two databases (EMBASE and PubMed) from their inception through July 19, 2022 following PRISMA guidelines.

Recent Findings

We identified a total of 28 eligible observational studies that evaluated the associations between 31 different PFAS exposures and metabolomics in humans. The most common exposure evaluated was legacy long-chain PFAS. Population sample sizes ranged from 40 to 1,105 participants at different stages across the lifespan. A total of 19 studies used a non-targeted metabolomics approach, 7 used targeted approaches, and 2 included both. The majority of studies were cross-sectional (n = 25), including four with prospective analyses of PFAS measured prior to metabolomics.

Summary

Most frequently reported associations across studies were observed between PFAS and amino acids, fatty acids, glycerophospholipids, glycerolipids, phosphosphingolipids, bile acids, ceramides, purines, and acylcarnitines. Corresponding metabolic pathways were also altered, including lipid, amino acid, carbohydrate, nucleotide, energy metabolism, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. We found consistent evidence across studies indicating PFAS-induced alterations in lipid and amino acid metabolites, which may be involved in energy and cell membrane disruption.

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PFAS暴露与人类代谢组:流行病学研究的系统综述
综述目的通过对人体代谢组的研究,人们对了解暴露于全氟烷基和多氟烷基物质(PFAS)对健康的影响越来越感兴趣。在这篇系统综述中,我们旨在确定PFAS和代谢组学特征之间的一致发现。根据PRISMA指南,我们对两个数据库(EMBASE和PubMed)从建立到2022年7月19日期间由两位作者独立审查的特定关键词进行了搜索匹配。最近的发现我们总共确定了28项符合条件的观察性研究,评估了31种不同的PFAS暴露与人类代谢组学之间的关系。最常见的暴露评估是遗留的长链PFAS。总体样本量从40人到1105人不等,他们处于生命的不同阶段。共有19项研究使用了非靶向代谢组学方法,7项研究使用了靶向方法,2项研究两者都使用。大多数研究是横断面的(n = 25),包括四项在代谢组学之前测量PFAS的前瞻性分析。研究中最常见的关联是观察到PFAS与氨基酸、脂肪酸、甘油磷脂、甘油脂、磷脂、胆汁酸、神经酰胺、嘌呤和酰基肉碱之间的关联。相应的代谢途径也发生了变化,包括脂质、氨基酸、碳水化合物、核苷酸、能量代谢、聚糖的生物合成和代谢以及辅助因子和维生素的代谢。我们在研究中发现了一致的证据,表明pfas诱导脂质和氨基酸代谢物的改变,这可能涉及能量和细胞膜破坏。
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来源期刊
Current Pollution Reports
Current Pollution Reports Environmental Science-Water Science and Technology
CiteScore
12.10
自引率
1.40%
发文量
31
期刊介绍: Current Pollution Reports provides in-depth review articles contributed by international experts on the most significant developments in the field of environmental pollution.By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to identification, characterization, treatment, management of pollutants and much more.
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