Успешное лечение пациента с плевропульмональной бластомой и множественными костными метастазами: клинический случай

Abstract

Background. Pleuropulmonary blastoma (PPB) is a rare primary embryonal tumor of the lung in children. Three main histological variants of PPB with a possible transformation of type I into type II and III are now described. The prognosis in pleuropulmonary blastoma patients with distant metastases is considered to be unfavorable. Case Report. The article presents the case of type I PPB development in a 14-month-old child followed by the transformation of type I PPB into type II in the setting of relapse with multiple bone metastases. The aim of the article was to provide reliable data on successful treatment and achievement of long-term event-free survival in a PPB patient with multiple bone metastases who underwent intensive chemotherapy and high-dose therapy with autologous hematopoietic stem cell transplantation. Conclusion . The case study demonstrates the possibility for achievement of long-term event-free survival in PPB patients with multiple bone metastases and relapses.