THE MECHANISMS OF THE MUSCLE PARALYSING ACTIONS OF ANTIBIOTICS, AND THEIR INTERACTION WITH NEUROMUSCULAR BLOCKING AGENTS

Abstract

2. THE AMINOGLYCOSIDES 131 2.1. Neuromuscular Effects 131 2.2. Mechanism of A ction 131 2.2.1. Prejunctional Actions 132 2.2.2. Postjunctional Effects 133 2.3. Chelation and Competitive Hypotheses 134 3. THE POLYMYXINS 135 3.1. Neuromuscular Effects 135 3.2. Mechanism of Action 136 3.2.1. Prejunctional Actions 137 3.2.2. Postjunctional Actions 137 3.2.3. Local Anaesthetic Action 138 4. THE TETRACYCLINES 1 3 8 4.1. Neuromuscular Effects 138 4.2. Mechanism of Action 139 5. THE LINCOSAMIDES 140 5.1. Neuromuscular Effects 140 5.2. Lincomycin 141 5.3. Clindamycin 142 6. REVERSIBILITY OF ANTIBIOTIC-INDUCED PARALYSIS 1 4 3 7. REFERENCES 146