75 Years of Vitamin A Production: A Historical and Scientific Overview of the Development of New Methodologies in Chemistry, Formulation, and Biotechnology

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED Organic Process Research & Development Pub Date : 2023-08-14 DOI:10.1021/acs.oprd.3c00161

Werner Bonrath, Bo Gao, Peter Houston, Tom McClymont, Marc-André Müller, Christian Schäfer, Christiane Schweiggert, Jan Schütz and Jonathan A. Medlock*,

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引用次数: 1

Abstract

In 1948, the first kilograms of synthetic vitamin A (acetate) were produced by F. Hoffmann-La Roche, eliminating the need to extract this vital compound from natural sources; this year marks 75 years of successful production. Since then, a number of chemical routes have been commercialized. Of these, three processes have stood the test of time and are still in use today, with only minor modifications. This review covers both the historical and scientific developments in the production of vitamin A derivatives from their beginnings up until recent developments including a fully catalytic process and the successful pilot-scale production via fermentation. In addition, the development of formulation technologies, which have gone hand-in-hand with chemical process development, is described; correct formulation is essential for stabilizing vitamin A derivatives which are sensitive to light and oxidation.

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75年的维生素A生产:化学、配方和生物技术新方法发展的历史和科学概述

1948年，F. Hoffmann-La Roche生产了第一批合成维生素A(醋酸盐)，不再需要从天然来源中提取这种重要的化合物;今年是成功制作75周年。从那时起，一些化学路线已经商业化。其中，有三种工艺经受住了时间的考验，至今仍在使用，只做了微小的修改。本文综述了维生素A衍生物生产的历史和科学发展，从一开始到最近的发展，包括全催化过程和通过发酵成功的中试规模生产。此外，描述了与化学工艺发展齐头并进的配方技术的发展;正确的配方对于稳定对光和氧化敏感的维生素A衍生物至关重要。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.

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