Review of the pharmacokinetics of nanodrugs

IF 6.1 3区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Nanotechnology Reviews Pub Date : 2023-01-01 DOI:10.1515/ntrev-2022-0525
Xiaotong Shao, Changkuo Shi, Shuqing Wu, Fei Wang, Wenliang Li
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引用次数: 1

Abstract

Abstract Nanodrug delivery systems (NDDSs) are a hotspot of new drug delivery systems with great development potential. They provide new approaches to fighting against diseases. NDDSs are specially designed to serve as carriers for the delivery of active pharmaceutical ingredients to their target sites, and their unique physicochemical characteristics allow for prolonged circulation time, improved targeting, and avoidance of drug resistance. Despite remarkable progress achieved in the preparation and efficacy evaluation of NDDSs, the understanding of the in vivo pharmacokinetics of NDDSs is still insufficient. Analysis of NDDSs is far more complicated than that for small molecular drugs; thus, almost all conventional techniques are inadequate for accurate profiling of their pharmacokinetic behaviour in vivo. In this article, we systematically reviewed the absorption, distribution, metabolism, and excretion of NDDSs and summarized the advanced bioanalytic techniques for tracing the in vivo fate of NDDSs. We also reviewed the physiologically based pharmacokinetic model of NDDS, which has been a useful tool in characterizing and predicting the systemic disposition, target exposure, and efficacy/toxicity of various types of drugs when coupled with pharmacodynamic modelling. We hope that this review will be helpful in improving the understanding of NDDS pharmacokinetics and facilitating the development of NDDSs.
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纳米药物的药代动力学研究进展
摘要纳米给药系统是新型给药系统的研究热点,具有很大的发展潜力。它们提供了对抗疾病的新方法。ndds是专门设计用于将活性药物成分递送到其靶点的载体,其独特的物理化学特性允许延长循环时间,提高靶向性,避免耐药。尽管在ndds的制备和疗效评价方面取得了显著进展,但对ndds体内药代动力学的了解仍然不足。ndds的分析远比小分子药物复杂;因此,几乎所有的传统技术都不足以准确描述它们在体内的药代动力学行为。本文系统地综述了NDDSs的吸收、分布、代谢、排泄等方面的研究进展,并对NDDSs的生物分析技术进行了综述。我们还回顾了基于生理的NDDS药代动力学模型,该模型与药效学模型相结合,已成为表征和预测各种药物的全身处置、靶暴露和功效/毒性的有用工具。希望本文综述有助于提高对NDDS药代动力学的认识,促进NDDS的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nanotechnology Reviews
Nanotechnology Reviews CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
11.40
自引率
13.50%
发文量
137
审稿时长
7 weeks
期刊介绍: The bimonthly journal Nanotechnology Reviews provides a platform for scientists and engineers of all involved disciplines to exchange important recent research on fundamental as well as applied aspects. While expert reviews provide a state of the art assessment on a specific topic, research highlight contributions present most recent and novel findings. In addition to technical contributions, Nanotechnology Reviews publishes articles on implications of nanotechnology for society, environment, education, intellectual property, industry, and politics.
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