Expressão imunohistoquímica do fator indutor de hipóxia 1-alfa (HIF-1α) em pacientes com câncer de mama localmente avançado

Abstract

____________________________________________________________________ BRITO, L.G.O. Immunohistochemical expression of hypoxia-inducible factor 1-alpha in locally advanced breast cancer patients. 2010. Master’s paper – Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2010. Objectives: To assess the expression of HIF-1α and its associated variables with locally advanced breast cancer (LABC) patients. Methods: Twenty-seven women were submitted to incisional biopsy for histopathological diagnosis of breast carcinoma and undertaken to neoadjuvant chemotherapy (NACT). It was studied the association of HIF-1α with age, tumoral size, histological grade, clinical stage, hormonal and axillary status, clinical and pathological response after NACT, expression of estrogen and progesterone receptors, as well as the presence of cerbB2 antigen. Results: HIF-1α ́s expression was found in 66.7% of patients. Only axillary status was the associated factor with its presence (p=0.02), and remained after univariate analysis. The others did not present any significant statistically difference. Conclusion: There is a significant statistically association between axillary status and HIF-1α ́s expression in LABC patients.