{"title":"Beneficial Effects of Urapidil Against Renal Ischemia Reperfusion-Related Renal Injury","authors":"A. Tanyeli̇","doi":"10.14744/scie.2022.89421","DOIUrl":null,"url":null,"abstract":"Objective: The potential protective effects of urapidil (Ura) against renal injury composed by ischemia reperfusion (I/R) were examined. Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondialdehyde (MDA) parameters were determined. Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined due to Ura administration. Conclusion: The results of the study showed that Ura is highly effective against renal damage induced by I/R. ABSTRACT","PeriodicalId":33982,"journal":{"name":"Southern Clinics of Istanbul Eurasia","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Southern Clinics of Istanbul Eurasia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14744/scie.2022.89421","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The potential protective effects of urapidil (Ura) against renal injury composed by ischemia reperfusion (I/R) were examined. Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondialdehyde (MDA) parameters were determined. Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined due to Ura administration. Conclusion: The results of the study showed that Ura is highly effective against renal damage induced by I/R. ABSTRACT
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