Electrochemical Evaluation of Catalytic Effect of Aluminum in Oxidation the Paracetamol in Human Blood

Abstract

The reactivity of paracetamol (Pa) using the carbon paste electrode (CPE) modified by the aluminum (CPE-Al) was reported. The working electrode was prepared by mixing the aluminum with the carbon powder. The optimal potential window was selected from -1.7 V to 1.7 V. The effect of parameters such as pH, scan rate, accumulation time and concentration were affected by cyclic voltammetry (CV) and square wave voltammetry (SWV). The optimal preconcentration time is 8 minutes. The reactivity of Pa on the electroanalysis detector was characterized by the appearance of the anodic peak at 0.25 V in a solution of sodium sulfate (0.1 M, pH 7). The calculated limits of detection and quantification have been 8.28·10-9 and 2.74·10-8 mol L-1, respectively. Then relative standard deviation (RSD) at 2.0·10-5 mol L-1 Pa concentration was 4.08 % for nine repetitions. The analytical application was carried out in the detection of Pa in human blood with satisfying results.