Association analysis of LDLR gene polymorphisms with susceptibility to sudden deafness

Abstract

In order to explore the association of 3 SNPs of LDLR gene with susceptibility to sudden deafness (SD), serum lipid parameters were compared in 139 SD patients and 139 healthy individuals. Genotyping of the 3 SNPs, allele and genotype frequencies were performed and compared. The association between allele frequency of 3 SNPs and susceptibility to SD in different models were analysed. Serum lipid parameters were compared in patients with different genotypes. The comparison of serum lipid levels showed higher triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels in patients compared to the controls. The frequencies of rs5929 T allele, rs2738464 G allele and rs1433099 T allele in SD group were higher than control group. We observed a statistically significant association of LDLR gene rs5929 T allele under dominant genetic model, rs2738464 G allele under additive and dominant genetic models, rs1433099 T allele under dominant genetic model with susceptibility to SD. There was no statistical difference in serum lipid levels of SD patients with different genotypes. Total cholesterol, triglycerides, and low-density lipoprotein cholesterol may be risk factors in the pathogenesis of SD. rs5929 T allele, rs2738464 G allele and rs1433099 T allele may be risk factors for SD. *Correspondence to: Xiaotong Zhang, Department of OtorhinolaryngologyHead and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157. West 5th Road, Xi'an City, Shaanxi Province, China, Tel: 86 29 8266 8888; E-mail: tracylizhang@189.cn