Measurable (Minimal) Residual Disease—A Meaningful Biomarker in Multiple Myeloma

IF 0.7 1区历史学 Q1 HISTORY Oral History Review Pub Date : 2016-01-01 DOI:10.17925/OHR.2016.12.02.75

M. Bhutani, S. Usmani

引用次数: 0

Abstract

I ndividual studies and meta-analyses highlight superior survival outcomes among those multiple myeloma patients achieving measurable residual disease (MRD) negative status. With the availability of next-generation flow cytomery and sequencing technologies, it is realistically possible to track MRD response in every patient. As the scientific evidence mounts, MRD is being established as a desired end-point for clinical trials. Future efforts should be directed at validating MRD as a surrogate biomarker for developing curative strategies and determining how MRD can be used to guide therapeutic decisions.

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可测量(最小)残留病——多发性骨髓瘤的有意义的生物标志物

个体研究和荟萃分析强调，在达到可测量残余疾病(MRD)阴性状态的多发性骨髓瘤患者中，生存率更高。随着下一代流式细胞术和测序技术的可用性，跟踪每个患者的MRD反应实际上是可能的。随着科学证据的增加，MRD正被确立为临床试验的理想终点。未来的努力应该指向验证MRD作为制定治疗策略的替代生物标志物，并确定MRD如何用于指导治疗决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral History Review Multiple-

CiteScore

1.20

自引率

27.30%

发文量

期刊介绍： The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.