An Exciting New Era in the Treatment of Myeloproliferative Neoplasms

IF 0.7 1区历史学 Q1 HISTORY Oral History Review Pub Date : 2016-01-01 DOI:10.17925/OHR.2016.12.02.71

N. Daver, R. Assi

引用次数: 0

Abstract

M yeloproliferative neoplasms (MPNs), including primary myelofibrosis and myelofibrosis (MF) evolving from a pre-existing MPN (post polycythemia veraand post essential thrombocythemia-myelofibrosis) are clonal hematopoietic stem cell disorders with heterogeneous symptoms, mutational profile, transformation risk and prognosis. Given the potentially chronic disease course, the goal of therapy in MF is to alleviate associated signs and symptoms, including reduction in spleen size, weight gain, improved performance status, and control of constitutional symptoms, leading to a prolonged survival and reduced transformation to leukemia.

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骨髓增殖性肿瘤治疗的新时代

骨髓增生性肿瘤(MPN)，包括原发性骨髓纤维化和由先前存在的MPN演变而来的骨髓纤维化(多发性红细胞增多症和原发性血小板增多症-骨髓纤维化)是一种克隆性造血干细胞疾病，具有异质性症状、突变特征、转化风险和预后。考虑到潜在的慢性病程，MF治疗的目标是缓解相关的体征和症状，包括脾脏大小减小、体重增加、改善运动状态和控制体质症状，从而延长生存期并减少向白血病的转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral History Review Multiple-

CiteScore

1.20

自引率

27.30%

发文量

期刊介绍： The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.