New Advances in the Treatment of Non-Small Cell Lung Cancer

IF 0.7 1区历史学 Q1 HISTORY Oral History Review Pub Date : 2018-01-01 DOI:10.17925/OHR.2018.14.1.18

S. Ramalingam

引用次数: 1

Abstract

Support: No funding was received in the publication of this article. Q. Could you tell us a little about the PACIFIC trial in stage III nonsmall cell lung cancer (NSCLC)? The PACIFIC trial evaluated the role of durvalumab, a programmed death-ligand 1 (PD-L1) antibody, in patients with locally advanced, surgically unresectable stage III NSCLC. Following completion of chemotherapy and radiation, patients were randomized to receive one year of durvalumab or placebo. There was a significant improvement in progression-free survival (PFS) with durvalumab, with a hazard ratio of 0.52. The survival data are awaited. The results of the PACIFIC study have defined a new role for immunotherapy in the treatment of NSCLC. Clinical benefit was seen regardless of PD-L1 expression status.

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非小细胞肺癌治疗的新进展

支持:本文的出版未收到任何资助。问:您能给我们介绍一下PACIFIC在III期非小细胞肺癌(NSCLC)中的临床试验吗?PACIFIC试验评估了durvalumab(一种程序性死亡配体1 (PD-L1)抗体)在局部晚期、手术不能切除的III期NSCLC患者中的作用。完成化疗和放疗后，患者随机接受一年的durvalumab或安慰剂治疗。杜伐单抗显著改善了无进展生存期(PFS)，风险比为0.52。生存数据仍在等待中。PACIFIC研究的结果确定了免疫疗法在非小细胞肺癌治疗中的新作用。无论PD-L1表达状态如何，临床获益均可见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral History Review Multiple-

CiteScore

1.20

自引率

27.30%

发文量

期刊介绍： The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.

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