Why CDK 4/6 Inhibitors are Practice Changing in Advanced Breast Cancer

IF 0.7 1区历史学 Q1 HISTORY Oral History Review Pub Date : 2020-01-01 DOI:10.17925/ohr.2020.16.1.23

N. McAndrew, Kelly E McCann

引用次数: 1

Abstract

Systemic therapy for advanced, hormone receptor-positive (HR+), human epidermal growth factor receptor 2-unamplified (HER2-) breast cancer has drastically evolved over the past several decades, from oophorectomy to combination endocrine and molecularly targeted therapy. Cyclin-dependent kinase (CDK) 4/6 inhibitors are the latest addition to this arsenal of therapies, and while they have been rapidly adopted by most oncologists, many still question whether they belong in the first-line metastatic setting. Recent reporting of overall survival data, however, has re-invigorated the debate and strongly supports first-line use of CDK 4/6 inhibitors. This article will provide an overview of the evolution of systemic therapy in HR+, HER2breast cancer, summarize the data that led to the approval of CDK 4/6 inhibitors, detail the new overall survival data reported in the PALOMA-3, MONALEESA-7, MONALEESA-3, and MONARCH-2 trials, and then discuss why our patients should receive these drugs in the first-line setting for advanced disease.

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为什么cdk4 /6抑制剂在晚期乳腺癌中的应用发生了变化

在过去的几十年里，晚期、激素受体阳性(HR+)、人表皮生长因子受体2-未扩增(HER2-)乳腺癌的全身治疗发生了巨大的变化，从卵巢切除术到内分泌和分子靶向联合治疗。细胞周期蛋白依赖性激酶(CDK) 4/6抑制剂是这一疗法库的最新成员，虽然它们已被大多数肿瘤学家迅速采用，但许多人仍然质疑它们是否属于一线转移性环境。然而，最近的总体生存数据报告重新激起了争论，并强烈支持一线使用cdk4 /6抑制剂。本文将概述HR+、her2型乳腺癌全身治疗的发展，总结导致cdk4 /6抑制剂获批的数据，详细介绍PALOMA-3、MONALEESA-7、MONALEESA-3和monarch2试验中报告的新的总生存数据，然后讨论为什么我们的患者应该在晚期疾病的一线环境中接受这些药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral History Review Multiple-

CiteScore

1.20

自引率

27.30%

发文量

期刊介绍： The Oral History Review, published by the Oral History Association, is the U.S. journal of record for the theory and practice of oral history and related fields. The journal’s primary mission is to explore the nature and significance of oral history and advance understanding of the field among scholars, educators, practitioners, and the general public. The Review publishes narrative and analytical articles and reviews, in print and multimedia formats, that present and use oral history in unique and significant ways and that contribute to the understanding of the nature of oral history and memory. It seeks previously unpublished works that demonstrate high-quality research and that offer new insight into oral history practice, methodology, theory, and pedagogy. Work published in the journal arises from many fields and disciplines, reflecting the interdisciplinary nature of oral history. While based in the U.S., the Review reflects the international scope of the field and encourages work from international authors and about international topics.

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